Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection

Molecular Microbiology

Volumn 44, Issue 2, 2002, Pages 431-448

  Smith, Alexander W ^a   Roche, Hazeline ^a   Trombe, Marie Claude ^b   Briles, David E ^a   Håkansson, Anders ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE DERIVATIVE; DIHYDROLIPOAMIDE DEHYDROGENASE; GALACTOSE; GALACTOSIDE; MELIBIOSE; OXIDOREDUCTASE; POLYSACCHARIDE; RAFFINOSE; STACHYOSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CARBOHYDRATE METABOLISM; CARBOHYDRATE SYNTHESIS; CARBON SOURCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; HOST; LUNG INFECTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SEPSIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; SUGAR TRANSPORT;

ALPHA-GALACTOSIDASE; AMINO ACID SEQUENCE; DIHYDROLIPOAMIDE DEHYDROGENASE; GENE DELETION; GENES, BACTERIAL; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OPEN READING FRAMES; PHYLOGENY; PNEUMOCOCCAL INFECTIONS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOCOCCUS PNEUMONIAE; TRANSFORMATION, BACTERIAL;

ANIMALIA; BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 0036228111     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02883.x     Document Type: Article

References (52)

1. Virulence of Streptococcus pneumoniae in mice: A standardized method for preparation and frozen storage of the experimental bacterial inoculum
2. Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes
3. Identification of a disaccharide unit of a glycoconjugate receptor for pneumococci attaching to human pharyngeal epithelial cells
4. The NADH oxidase of Streptococcus pneumoniae: Its involvement in competence and virulence
5. The protective action of a specific enzyme against type III pneumococcus infection in mice
6. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a dexoxyribonucleic acid fraction isolated from pneumococcus type III
7. DNA sequence sampling and gene disruption for identification of new anti-bacterial targets in Streptococcus pneumoniae
8. CpsB is a modulator of capsule-associated tyrosine kinase activity in Streptococcus pneumoniae
9. 2-Oxo acid dehydrogenase multienzyme complexes. The central role of the lipoyl domain
10. Dihydrolipoamide dehydrogenase: Functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases
11. Archaebacteria: The comparative enzymology of their central metabolic pathways
12. Dihydrolipoamide dehydrogenase: A 'new' function for an old enzyme?
13. Dihydrolipoamide dehydrogenase from Trypanosoma brucei: Characterization and cellular localization
14. Purification and comparative studies of dihydrolipoamide dehydrogenases from the anaerobic, glycine-utilizing bacteria Peptostreptococcus glycinophilus, Clostridium cylindrosporum, and Clostridium sporogenes
15. Isolation, partial characterization and localization of a dihydrolipoamide dehydrogenase from the cyanobacterium Synechocystis PCC 6803
16. Preformulation study of the vaccine candidate P64k against Neisseria meningitidis
17. Identification of genes involved in utilization of acetate and acetoin in Bacillus subtilis
18. Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase
19. An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae
20. Bacterial metabolism. I. Lactic acid production by haemolytic streptococci
21. An NADH-linked spectrophotometric assay for pyruvate dehydrogenase complex in crude tissue homogenates
22. Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway
23. Fission yeast dihydrolipoamide dehydrogenase gene is involved in G1/S cell cycle progression
24. Carbohydrate metabolism in lactic acid bacteria
25. Isolation and purification of a substance inducing competence and inactivating transforming DNA in Pneumococcus
26. The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria
27. Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase enzyme system
28. Molecular structure of the lipoamide dehydrogenase domain of a surface antigen from Neisseria meningitidis
29. Purification and characterization of the E1 component of the Clostridium magnum acetoin dehydrogenase enzyme system
30. Requirement for capsule in colonization by Streptococcus pneumoniae
31. Refined crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii at 2.2 Å resolution. A comparison with the structure of glutathione reductase
32. Lipoic acid metabolism in Escherichia coli: The lplA and lipB genes define redundant pathways for ligation of lipoyl groups to apoprotein
33. Isolation of transformation-deficient Streptococcus pneumoniae mutants defective in control of competence, using insertion-duplication mutagenesis with the erythromycin resistance determinant of pAMβ1
34. On growing the pneumococcus with a view to the production of standard maximal density, virulence and polysaccharide content
35. Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system
36. Structure and posttranslational modification of lipoyl domain of 2-oxo-acid dehydrogenase multienzyme complexes
37. 2-Oxo acid dehydrogenase multi-enzyme complexes: In the beginning and halfway there
38. Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: Significance of lipoate attachment
39. Purification of the pyruvate dehydrogenase complex (Escherichia coli)
40. Studies on the nature and reactions of protein-bound lipoic acid
41. Binding protein-dependent transports in 2-oxo acids dehydrogenase mutants of Escherichia coli
42. Purification of a new dihydrolipoamide dehydrogenase from Escherichia coli
43. Galactose- and maltose-stimulated lipoamide dehydrogenase activities related to the binding-protein-dependent transport of galactose and maltose in toluenized cells of Escherichia coli
44. Regulation of the α-galactosidase activity in Streptococcus pneumoniae: Characterization of the raffinose utilization system
45. Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme
46. Site-directed mutagenesis of the dihydrolipoyl transacetylase component (E2p) of the pyruvate dehydrogenase complex from Azotobacter vinelandii. Binding of the peripheral components E1p and E3
47. α-keto acid dehydrogenase complexes. 13. Reaction of sulfhydryl groups in pyruvate dehydrogenase with organic mercurials
48. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae
49. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
50. The mammalian pyruvate dehydrogenase complex: Structure and regulation
51. Lipoamide dehydrogenase, glutathione reductase, thioredoxin reductase, and mercuric reductase - A family of flavoenzyme transhydrogenases
52. Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA gene