Synthesis and spasmolytic action of 2-substituted thienopyrimidin-4-one derivatives

Journal of Pharmacy and Pharmacology

Volumn 54, Issue 5, 2002, Pages 717-728

  Santagati, Natale Alfredo ^a   Prezzavento, Orazio ^a   Bousquet, Ennio ^a   Ronsisvalle, Giuseppe ^a   Spampinato, Santi ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 (DIETHYLAMINO)ETHYL]THIO] 3 PHENYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 [[2 (DIETHYLAMINO)ETHYL]THIO] 5,6 DIMETHYL 3 (4 METHYLPHENYL)THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 MERCAPTO 3 (4 METHYLPHENYL)THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 MERCAPTO 3 (4 METHYLPHENYL)THIENO[3,2 D]PYRIMIDIN 4(3H) ONE; 2 MERCAPTO 3 PHENYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 MERCAPTO 3 PHENYLTHIENO[3,2 D]PYRIMIDIN 4(3H) ONE; 2 MERCAPTO 5,6 DIMETHYL 3 (4 METHYLPHENYL) THIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 THIENO[2,3 D]PYRIMIDIN 4 ONE; 2 THIENO[3,2 D]PYRIMIDIN 4 ONE; 3 (4 CHLOROPHENYL) 2 [[2 (DIETHYLAMINO)ETHYL]THIO] 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 2 MERCAPTO 5,6 DIMETHYLTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 2 MERCAPTOTHIENO[2,3 D]PYRIMIDIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 2 MERCAPTOTHIENO[3,2 D]PYRIMIDIN 4(3H) ONE; ACETYLCHOLINE; CALCIUM CHANNEL L TYPE; ETHYL 2 [[[(4 CHLOROPHENYL)AMINO]CARBONOTHIOYL]AMINO] 4,5 DIMETHYLTHIOPENE 3 CARBOXYLIC ACID; ETHYL 4,5 DIMETHYL 2 [[[(4 METHYLPHENYL)AMINO]CARBONITHIOYL]AMINO]THIOPENE 3 CARBOXYILC ACID; GUANYLATE CYCLASE; HISTAMINE; METHYL 2 [(ANILINOCARBONOTHIOYL)AMINO]THIOPENE 3 CARBOXYLIC ACID; METHYL 2 [[[(4 CHLOROPHENYL)AMINO]CARBONOTHIOYL]AMINO]THIOPENE 3 CARBOXYLIC ACID; METHYL 2 [[[(4 METHYLPHENYL)AMINO]CARBONOTHIOYL]AMINO]THIOPENE 3 CARBOXYLIC ACID; METHYL 3 [(ANILINOCARBONOTHIOYL)AMINO]THIOPENE 2 CARBOXYLIC ACID; METHYL 3 [[[(4 CHLOROPHENYL)AMINO]CARBONOTHIOYL]AMINO]THIOPHENE 2 CARBOXYLIC ACID; METHYL 3 [[[(4 METHYLPHENYL)AMINO]CARBONOTHIOYL]AMINO]THIOPHENE 2 CARBOXYLIC ACID; MUSCARINIC RECEPTOR; PHOSPHODIESTERASE INHIBITOR; PYRIMIDINE DERIVATIVE; THIENOPYRIMIDIN 4 ONE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HEART; HEART VENTRICLE; HOMOGENATE; IC 50; ILEUM; ILEUM CONTRACTION; INHIBITION KINETICS; MALE; MUSCLE DISEASE; NONHUMAN; RAT; SMOOTH MUSCLE SPASM; SOLUBILITY; SPASMOLYSIS; STRUCTURE ANALYSIS; SUBMANDIBULAR GLAND;

ANIMALS; CALCIUM CHANNELS, L-TYPE; ELECTRIC STIMULATION; GUINEA PIGS; ILEUM; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PARASYMPATHOLYTICS; PYRIMIDINONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; THIOPHENES;

EID: 0036227891     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021778871     Document Type: Article

References (25)

1. Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics
2. 50) of an enzymatic reaction
3. Investigation of the antimuscarinic and other actions of proadifen in vitro
4. Functional gut disorders: From motility to sensitivity disorders. A review of current and investigational drugs for their management
5. Subtypes of the muscarinic receptor in smooth muscle
6. 3 muscarinic receptors in gastrointestinal smooth muscle
7. 2+ for muscarinic receptor-induced contraction in the rat ileum
8. Otilonium bromide: A selective spasmolytic for the gastrointestinal tract
9. 2-Amino-thiophene aus methylenaktiven nitrilen, carbonylverbindungen und schwefel
10. Assay for calcium channels
11. Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea pig ileum
12. Protein measurement with the folin phenol reagent
13. 2 muscarinic receptor antagonists
14. Ligand: A versatile computerised approach for characterization of ligand binding systems
15. New basic esters of 2-phenyl-2-methyl-4-oxo-4H-1-benzopyran-8-carboxylic acid endowed with spasmolytic properties
16. Beta-adrenergic agonists and cyclic AMP decrease intracellular resting free-calcium concentration in ileum smooth muscle
17. Gastrointestinal receptors and drugs in motility disorders
18. Synthesis and pharmacological activity of 2-alkylthio substituted thieno[2,3-d]pyrimidin-4-one and 5H-pyrimido[5,4-b]indol-4-one
19. 2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon
20. Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases
21. Depressant action of oxybutynin on the contractility of intestinal and urinary tract smooth muscle
22. 3H]-N-methylscopolamine binding to muscarinic receptors in the rat central nervous system: Evidence for the existence of three classes of binding sites
23. Muscarinic antagonists in development for disorders of smooth muscle function
24. Inhibitory transmission to the longitudinal muscle of the mouse caecum is mediated largely by nitric oxide acting via soluble guanylyl cyclase