Timing and structural consideration for the processing of mitochondrial matrix space proteins by the mitochondrial processing peptidase (MPP)

Protein Science

Volumn 11, Issue 5, 2002, Pages 1026-1035

  Mukhopadhyay, Abhijit ^a   Hammen, Philip ^a   Waltner Law, Mary ^a   Weiner, Henry ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Aldehyde dehydrogenase; Leader peptide processing; Mitochondrial processing peptidase; Mitochondrial protein processing; MPP; Precursor protein

Indexed keywords

ALDEHYDE DEHYDROGENASE; AMINO ACID; MATRIX PROTEIN; METALLOPROTEINASE; PEPTIDASE; PROTEIN PRECURSOR; PROTEINASE; RECOMBINANT PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; HYDROLYSIS; MITOCHONDRION; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; YEAST;

ALDEHYDE DEHYDROGENASE; AMINO ACID SEQUENCE; ESCHERICHIA COLI; METALLOENDOPEPTIDASES; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SORTING SIGNALS; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 0036227884     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.3760102     Document Type: Article

References (34)

1. Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20
2. cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacylCoA thiolase with no transient presequence: Structural relationship with peroxisomal isozyme
3. Characterization of the mitochondrial processing peptidase of Neurospora crassa
4. Modeling unfolded states of peptides and proteins
5. Studies on the topology of the protein import channel in relation to the plant mitochondrial processing peptidase integrated into the cytochrome bcl complex
6. Cleavage-site motifs in mitochondrial targeting peptides
7. Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence
8. Isolation of highly purified mitochondria from Saccharomyces cerevisiae
9. Amphiphilicity determines binding properties of three mitochondrial presequences to lipid surfaces
10. The role of positive charges and structural segments in the presequence of rat liver aldehyde dehydrogenase in import into mitochondria
11. Amino-terminal deletions in the presequence of an imported mitochondrial protein block the targeting function and proteolytic cleavage of the presequence at the carboxy terminus
12. Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli
13. Rat liver mitochondrial intermediate peptidase (MIP): Purification and initial characterization
14. 2D NMR and structural model for a mitochondrial signal peptide bound to a micelle
15. Determinants in the presequence of cytochrome b2 for import into mitochondria and for proteolytic processing
16. The general mitochondrial matrix processing protease from rat liver: Structural characterization of the catalytic subunit
17. Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space
18. Different structures in the amino-terminal domain of the ornithine transcarbamylase leader peptide are involved in mitochondrial import and carboxylterminal cleavage
19. The mitochondrial targeting function of randomly generated peptide sequences correlates with predicted helical amphiphilicity
20. The mitochondrial processing peptidase: Function and specificity
21. Expression of cloned bovine adrenal rhodanese
22. NMR identification of the Tom20 binding segment in mitochondrial presequences
23. Analysis of elements in the substrate required for processing by mitochondrial processing peptidase
24. Purification and characterization of a processing protease from rat liver mitochondria
25. The beta subunit of the mitochondrial processing peptidase from rat liver: Cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidases
26. Polypeptides traverse the mitochondrial envelope in an extended state
27. Feature-extraction from endopeptidase cleavage sites in mitochondrial targeting peptides
28. Studies on protein processing for membrane-bound spinach leaf mitochondrial processing peptidase integrated into the cytochrome bcl complex and the soluble rat liver matrix mitochondrial processing peptidase
29. Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase
30. Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion
31. Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences
32. Import, processing, and two-dimensional NMR structure of a linker-deleted signal peptide of rat liver mitochondrial aldehyde dehydrogenase
33. Conversion of a nonprocessed mitochondrial precursor protein into one that is processed by the mitochondrial processing peptidase
34. The presequence of rat liver aldehyde dehydrogenase requires the presence of an alpha-helix at its N-terminal region which is stabilized by the helix at its C termini