Effects of tiagabine, a γ-aminobutyric acid re-uptake inhibitor, on normal rat bladder function

Journal of Urology

Volumn 167, Issue 5, 2002, Pages 2241-2246

  Pehrson, Rikard ^a   Andersson, Karl Erik ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acetylcholineamma aminobutyric acid; Bladder; Rats, Sprague Dawley; Urination

Indexed keywords

4 AMINOBUTYRIC ACID; CARBACHOL; TETRODOTOXIN; TIAGABINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER CAPACITY; BLADDER CONTRACTION; BLADDER FUNCTION; BLADDER MUSCLE; CONTROLLED STUDY; CYSTOMETRY; DRUG EFFECT; FEMALE; MICTURITION; MUSCLE ISOMETRIC CONTRACTION; MUSCLE TONE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0036226309     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)65136-1     Document Type: Article

References (32)

1. Effects of GABA-receptor stimulation and blockade on micturition in normal rats and rats with bladder outflow obstruction
2. Spinal and supraspinal components of GABAergic inhibition of the micturition reflex in rats
3. Modulation of detrusor contraction strength and micturition characteristics by intrathecal baclofen in anaesthetized rats
4. A double-blind crossover trial of baclofen: A new treatment for the unstable bladder syndrome
5. Effect of intrathecal baclofen on bladder and sphincter function
6. Voiding dysfunction in patients with spastic paraplegia: Urodynamic evaluation and response to continuous intrathecal baclofen
7. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
8. γ-aminobutyric acid in peripheral tissues
9. GABA and its receptors in the spinal cord
10. GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors
11. 3H-tiagabine
12. 3H]tiagabine (NNC05-328) to the GABA uptake carrier
13. The γ-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats
14. Treatment of overactive bladder: Other drug mechanisms
15. Cystometrical evaluation of bladder instability in rats with intravesical outflow obstruction
16. Effect of drugs interacting with adrenoreceptors and muscarinic receptors in the epididymal and prostatic parts of the human isolated vas deferens
17. A rat model for investigation of spinal mechanisms in detrusor instability associated with intravesical outflow obstruction
18. A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor
19. Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans
20. Tiagabine antinociception in rodents depends on GABA(B) receptor activation: Parallel antinociception testing and medial thalamus GABA microdialysis
21. B receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord
22. Receptor localisation in the mammalian dorsal horn and primary afferent neurons
23. The effects of baclofen on spinal and supraspinal micturition reflexes in rats
24. The pontine micturition centre projects to sacral cord GABA immunoreactive neurons in the cat
25. Rat: Overview and innervation
26. Central inhibition by gamma-aminobutyric acid of the release of vasopressin by carbachol in the rat
27. The effect of peripherally administered GABA on spontaneous contractions of rat urinary bladder in vivo
28. Involvement of central GABA receptors in the regulation of the urinary bladder function of anaesthetized rats
29. Neuronal GABA release and GABA inhibition of Ach release in guinea pig urinary bladder
30. γ-aminobutyric acid inhibits motility of the isolated guinea-pig urinary bladder
31. Inhibition in the human urinary bladder by gamma-amino-butyric acid
32. GABA-receptors in peripheral tissues