Melatonin blocks rat hippocampal neuronal apoptosis induced by amyloid beta-peptide 25-35

Journal of Pineal Research

Volumn 32, Issue 3, 2002, Pages 163-167

  Shen, Yu Xian ^a   Xu, Shu Yun ^a   Wei, Wei ^a   Wang, Xue Long ^a   Wang, H ^a   Sun, X ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Amyloid beta peptide; Apoptosis; Cell viability; Hippocampal neurons; Melatonin

Indexed keywords

AMYLOID BETA PROTEIN; DNA FRAGMENT; MELATONIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL STRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DEGRADATION; FLOW CYTOMETRY; HIPPOCAMPUS; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; RAT;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CELLS, CULTURED; DNA FRAGMENTATION; HIPPOCAMPUS; MELATONIN; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036226252     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079x.2002.1o839.x     Document Type: Article

References (22)

1. Melatonin protects primary cultures of rat cortical neurones from NMDA excitotoxicity and hypoxia/reoxygenation
2. + cells: A possible nuclear receptor-mediated mechanism involving Th1 lymphocytes and monocytes
3. Neuroprotection by melatonin from kainate-induced excitotoxicity in rats
4. Amyloid β-peptide is produced by cultured cells during normal metabolisrn
5. Melatonin protects nigral dopaminergic neurons from 1-methyl-4-phenypyridinium (MPP+) neurotoxicity in rats
6. Melatonin inhibits iron-induced epileptic discharges in rats by suppressing peroxidation
7. Apoptosis induced by serum deprivation of PC12 cells is not preceded by growth arrest and can occur at each phase of the cell cycle
8. Apoptosis is induced by β-amyloid in culture central nervous system neurons
9. Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats
10. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
11. Vulnerability of small GABAergic neurons to human beta-amyloid pentapeptide
12. An assessment of the antioxidant and antiamyloidogenic properties of melatonin: Implication for Alzheimer's disease
13. Melatonin prevents death of neuroblastoma cells exposed to Alzheimer amyloid peptide
14. Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons
15. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
16. Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
17. Oxidative damage in the central nervous system: Protection by melatonin
18. Exposure to N-methyl-D-aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes
19. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
20. Assessment of amyloid beta protein in cerebrospinal fluid as an aid in the diagnosis of Alzheimer's disease
21. Studies on the antiinflammatory, immunoregulatory, and analgesic actions of melatonin
22. Neurotrophic and neurotoxic effects of β amyloid protein: Reversal by tachykinin neuropeptides