Isolation and purification of an antitumor metabolite from Alternaria brassicicola SW-3, the cause of brassica black leaf spot disease

Korean Journal of Applied Microbiology and Biotechnology

Volumn 30, Issue 1, 2002, Pages 51-56

  Na, Yeo Jung ^a   Bang, Sook Lee ^a   Sung, Keon Namgoong ^a   Jung, Dong Sun ^a  

^a Seoul Women University   (South Korea)

Author keywords

Alternaria brassicicola; Antitumor activity; Depudecin; Fungal metabolites

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; CARBON; DEPUDECIN; DRUG METABOLITE; EPOXIDE; HYDROXYL GROUP; SILICA GEL; UNCLASSIFIED DRUG;

ALTERNARIA BRASSICICOLA; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRASSICA; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CYTOTOXICITY; DRUG ISOLATION; DRUG PURIFICATION; FUNGUS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0036225796     PISSN: 02572389     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Research on antibiotics screening in Japan over the last decade: A producing microorganism approach
2. Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their vincristine-resistant sublines
3. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth
4. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin
5. Alternaria toxins and their importance in food
6. An antibiotics complex from A. brassicicola
7. Depudecin: A novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and srconcogene, produced by Alternaria brassicicola
8. Depudecin, a microbial metabolite containing two epoxide groups, exhibits anti-angiogenic activity in vivo
9. Depudecin makes a debut
10. Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase
11. Synthesis and cellular characterization of the detransformation agent, (-)-depudecin
12. Biosynthesis of depudecin, a metabolite of Nimbya scirpicola
13. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
14. Phytotoxin produced by Nimbya scirpicola
15. Antiplasmodial compounds from the wood-decayed fungus Xylaria sp. BCC 1067