Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability

Cellular and Molecular Biology Letters

Volumn 7, Issue 1, 2002, Pages 92-95

  Potočnik, Uroš ^a   Ravnik Glavač, Metka ^a   Glavač, Damjan ^a  

^a INSTITUTE OF PATHOLOGY   (Slovenia)

Author keywords

Colorectal cancer; MDR1 mutations; MDR1 polymorphisms; Microsatellite instability; TCF4 mutations

Indexed keywords

GENE PRODUCT; MULTIDRUG RESISTANCE PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 1; UNCLASSIFIED DRUG;

ALLELE; CARCINOGENESIS; COLORECTAL TUMOR; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; EXON; FRAMESHIFT MUTATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; SIGNAL TRANSDUCTION;

EID: 0036225455     PISSN: 14258153     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (7)

1. Genetic susceptibility to non-polyposis colorectal cancer
2. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability
3. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis
4. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdrl (P-glycoprotein) gene
5. Naturally occuring mutations and functional polymorphisms in multidrug resistance 1 gene: Correlation with microsatellite instability and lymphoid infiltration in colorectal cancers
6. Causes of microsatellite instability in colorectal tumors: Implications for hereditary non-polyposis colorectal cancer screening
7. Identification of functionally variant MDR1 alleles among European Americans and African Americans