Identification of a new site in the S1 ligand binding region of the NMDA receptor NR2A subunit involved in receptor activation by glutamate

Neuropharmacology

Volumn 42, Issue 4, 2002, Pages 437-443

  Lummis, Sarah C R ^a,b   Fletcher, Elizabeth J ^a   Green, Tim ^c  

^a Nature   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Department of Pharmacology ^*  (United Kingdom)

Author keywords

Calcium imaging; Glutamate binding; HEK 293 cells; NMDA receptors; NR2 subunit; Site directed mutagenesis

Indexed keywords

GLUTAMIC ACID; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; HUMAN; HUMAN CELL; LIGAND BINDING; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; POINT MUTATION; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0036223467     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00002-3     Document Type: Article

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