Evidence for an association between plasma platelet-activating factor acetylhydrolase deficiency and increased risk of childhood atopic asthma

Journal of Human Genetics

Volumn 47, Issue 2, 2002, Pages 99-101

  Ito, S ^a   Noguchi, E ^a   Shibasaki, M ^a   Yamakawa Kobayashi, K ^a   Watanabe, H ^a   Arinami, T ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Association; Asthma; Genetic polymorphism; Platelet activating factor acetylhydrolase; Transmission disequilibrium test

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; PHENYLALANINE; THROMBOCYTE ACTIVATING FACTOR; VALINE;

ADULT; AGED; ALLERGIC ASTHMA; ARTICLE; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME DEFICIENCY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INFLAMMATION; JAPAN; MAJOR CLINICAL STUDY; MALE; MITE; RISK FACTOR;

ACARI;

EID: 0036221860     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380200009     Document Type: Article

References (11)

1. Release of platelet-activating factor (PAF-acether) and 2-lyso PAF-acether from three cell types
2. A mutation in plasma platelet-activating factor acetylhydrolase (Va1279 → Phe) is a genetic risk factor for stroke
3. Increased plasma platelet-activating factor in children with acute asthmatic attacks and decreased in vivo and in vitro production of platelet-activating factor after immunotherapy
4. Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children
5. Platelet-activating factor
6. Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma
7. Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase
8. Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma
9. Increased plasma levels of platelet-activating factor (PAF) and low serum PAF acetylhydrolase (PAFAH) activity in adult patients with bronchial asthma
10. Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma
11. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families