The protective effects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged rats

Journal of Pineal Research

Volumn 32, Issue 2, 2002, Pages 85-89

  Shen, Y X ^a   Xu, S Y ^a   Wei, W ^a   Sun, X X ^a   Liu, L H ^a   Yang, J ^a   Dong, C ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Antioxidative enzyme; Beta amyloid protein; Learning and memory; Lipid peroxidation; Melatonin

Indexed keywords

AMYLOID BETA PROTEIN; GLUTATHIONE PEROXIDASE; MELATONIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; COGNITION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; EVALUATION; HIPPOCAMPUS; LATENT PERIOD; LEARNING; LIPID PEROXIDATION; MAZE TEST; MEASUREMENT; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; SPATIAL ORIENTATION; SWIMMING;

AGE FACTORS; AMYLOID BETA-PROTEIN; ANIMALS; ANTIOXIDANTS; BRAIN; COGNITION; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS; LIPID PEROXIDATION; MAZE LEARNING; MELATONIN; MITOCHONDRIA; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0036221784     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079x.2002.1819.x     Document Type: Article

References (24)

1. Monozygotic twins with Alzheimer's disease treated with melatonin: Case report
2. Melatonin prevents beta-amyloid-induced lipid peroxidation
3. An amnestic effect in mice of four synthetic peptides homologous to amyloid β protein from patients with Alzheimer's disease
4. Amyloid β-peptide is produced by cultured cells during normal metabolism
5. Lack of protection of monoamine oxidase B-deficient mice from age-related spatial learning deficits in the morris water maze
6. Apoptosis is induced by β-amyloid in culture central nervous system neurons
7. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
8. Co-injection of β-amyloid with ibotenic acid induces synergistic loss rat hippocampal neurons
9. β-amyloid protein-induced Alzheimer's disease animal model
10. Inhibition of Alzheimer β-fibrillogenesis by melatonin
11. Evidence of oxidative stress and in vivo neurotoxicity of beta amyloid in a oxidative transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo
12. An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: Implications for Alzheimer's disease
13. The pineal aging clock. Evidence, models, mechanisms, interventions
14. Neuro-degeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
15. The aging pineal gland and its physiological consequences
16. Antioxidant action of melatonin
17. Melatonin: Mechanisms and actions as an antioxidant
18. The molecular pathology of Alzheimer's disease
19. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amloid-mediated cell death
20. Improvement of melatonin to learning and memory impairment induced by amyloid β-peptide 25∼35 in elder rats
21. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
22. Melatonin binding sites in the central nervous system
23. Melatonin: A potent, endogenous hydroxyl radical scavenger
24. 2+ channel blockers attenuate β-amloid peptide toxicity to cortical neurons in culture