Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation

Annals of Surgical Oncology

Volumn 9, Issue 3, 2002, Pages 310-316

  Mohiuddin, Imran ^a   Cao, Xiaobo ^a   Ozvaran, Mustafa K ^a   Zumstein, Lou ^a   Chada, Sunil ^a   Smythe, W Roy ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

AKT; Apoptosis; Mesothelioma; PTEN

Indexed keywords

ADENOVIRUS VECTOR; GENE PRODUCT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; ENZYME PHOSPHORYLATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; MESOTHELIOMA; NONHUMAN;

EID: 0036221096     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02573071     Document Type: Article

References (29)

1. Simian virus 40: The link with human malignant mesothelioma is well established
2. Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: Results in 183 patients
3. Chemotherapy in malignant mesothelioma: A review
4. Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene
5. Operation and photodynamic therapy for pleural mesothelioma: 6-Year followup
6. Effect of interferon-alpha 2a on malignant mesothelioma
7. Clinical and immunological evaluation of intrapleural interleukin-2 in malignant pleural mesothelioma: A phase II study
8. The European mesothelioma epidemic
9. Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: An effective in vitro drug sensitization system
10. PTEN, a unique tumor suppressor gene
11. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
12. PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis
13. Mutations of the human PTEN gene
14. PTEN gene and integrin signaling in cancer
15. Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with low malignancy: Results of a phase I clinical trial in malignant mesothelioma
16. Resistance of pleural mesothelioma cell lines to apoptosis: Relation to expression of bcl-2 and bax
17. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species
18. -)-cotransport blocker bumetanide
19. Talc induces apoptosis in human malignant mesothelioma cells in vitro
20. Lovastatin induces apoptosis in malignant mesothelioma cells
21. PTEN, a putative protein tyrosine kinase gene mutated in brain, breast and prostate cancer
22. Mutation spectrum and genotype-phenotype analysis in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
23. Mutation analysis of the PTEN/MMAC gene in lung cancer
24. PTEN/MMAC mutations identified in small cell but not in non-small cell lung cancers
25. MMAC/PTEN mutations in primary tumor specimens and tumor cell lines
26. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 arrest in human glioblastoma cells
27. Genetic alterations in pediatric high-grade astrocytomas
28. Mutational analysis of the PTEN gene in gliomas: Molecular and pathological correlations