Efficacy of L-carnitine in reducing hyperammonaemia and improving neuropsychological test performance in patients with hepatic cirrhosis: Results of a randomised trial

Clinical Drug Investigation

Volumn 22, Issue , 2002, Pages 7-14

  Cecere, Angelo ^a   Ciaramella, Francesco ^a   Tancredi, Luciano ^a   Romano, Ciro ^a   Gattoni, Adriano ^a  

^a NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE;

ADULT; AGED; ALCOHOL ABUSE; AMMONIA BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEPATIC ENCEPHALOPATHY; HEPATITIS B; HEPATITIS C; HUMAN; HYPERAMMONEMIA; LIVER CIRRHOSIS; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL; TASK PERFORMANCE; TREATMENT PLANNING;

EID: 0036220688     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-200222001-00002     Document Type: Article

References (24)

1. The pathogenesis and treatment of hepatic encephalopathy: Evidence for the involvement of benzodiazepine receptor ligands
2. Clinical manifestations and therapy of hepatic encephalopathy
3. Latent portosystemic encephalopathy: I. Nature of cerebral functional defects and their effect on fitness to drive
4. An analysis of the causes and prevention of hepatic coma
5. Molecular mechanism of acute ammonia toxicity and of its prevention by L-carnitine
6. The dynamics of ammonia metabolism in man
7. Animal models of hepatic encephalopathy and hyperammonemia
8. Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy
9. Double blind, double dummy comparison between treatment with rifaximin and lactulose in patients with medium to severe degree hepatic encephalopathy
10. Biosynthesis and metabolism of carnitine
11. Utilization of propionyl-L-carnitine for the treatment of heart failure
12. Primary carnitine deficiency
13. Disorders of lipid metabolism in muscle
14. Carnitine metabolism in chronic liver disease
15. New roles of carnitine metabolism in ammonia cytotoxicity
16. An approximate distribution of variance components
17. Acute systemic and splanchnic haemodynamic effects of L-carnitine in patients with cirrhosis
18. Effect of L-carnitine upon ammonia tolerance test in cirrhotic patients
19. The action of ammonia on astrocyte glycogen and glycogenolysis
20. Hepatic encephalopathy: A disorder in glial-neuronal communication
21. Effect of ammonium ions on synaptic transmission in the mammalian central nervous system
22. Astrocyte-neuron interactions in hyperammonemia and hepatic coma
23. Protective effects of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat
24. Carnitine transport defect presenting with hyperammonemia: Report of one case