Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets

Haematologica

Volumn 87, Issue 4, 2002, Pages 420-426

  Celestini, Andrea ^a   Pulcinelli, Fabio M ^a   Pignatelli, Pasquale ^a   Lenti, Luisa ^a   Frati, Giacomo ^a   Gazzaniga, Pier Paolo ^a   Violi, Francesco ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Aspirin; Collagen; Phospholipase C; Platelets; Vitamin E

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; CALCIUM; COLLAGEN; PHOSPHOLIPASE C;

ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NORMAL HUMAN; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOSIS;

ASPIRIN; BLOOD PLATELETS; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HUMANS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; VITAMIN E;

EID: 0036218799     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Radiolabeled native low-density lipoprotein injected into patients with carotid stenosis accumulates in macrophages of atherosclerotic plaque: Effect of vitamin E supplementation
2. Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration
3. Evidence for a rote for tyrosine phosphorylation of phospholipase C γ 2 in collagen-induced platelet cytosolic calcium activation
4. Vitamin E inhibits collagen-induced platelet activation by blunting hydrogen peroxide
5. Hydrogen peroxide is involved in collagen-induced platelet activation
6. Inhibitory effect of vitamin E (α-tocopherol) on spontaneous aggregation in whole blood
7. Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration
8. Platelet sequestration in men I: Methods
9. Determination of platelet adhesion to collagen and the associated formation of phosphatidic acid and calcium mobilization
10. Platelet 5-HT uptake and release stopped rapidly by formaldehyde
11. Adenine nucleotide metabolism of blood platelets. X. Formaldehyde stops centrifugation-induced secretion after A23187-stimulation and causes breakdown of metabolic ATP
12. 32P labelled inositol phosphates
13. 2+ indicators with greatly improved fluorescence properties
14. Antioxidants and ischemic heart disease
15. Platelet adhesion to native type I collagen fibrils. Role of GPVI in divalent cation-dependent and -independent adhesion and thromboxane A2 generation
16. Collagen receptor signaling in platelets and megakaryocytes
17. Vitamin E plus aspirin compared with aspirin alone in patients with transient ischemic attacks
18. Vitamin E and the risk of coronary disease
19. Vitamin E inhibition of platelet aggregation is independent of antioxidant activity