Timolol concentrations in rat ocular tissues and plasma after topical and intraperitoneal dosing

Journal of Glaucoma

Volumn 11, Issue 2, 2002, Pages 134-142

  Tan, Alexander Y ^a   LeVatte, Terry L ^a   Archibald, Michele L ^a   Tremblay, François ^a   Kelly, Melanie E M ^a   Chauhan, Balwantray C ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

HPLC; Intraocular tissue concentrations; Intraperitoneal dosing; Rat; Timolol; Topical dosing

Indexed keywords

TIMOLOL MALEATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CILIARY BODY; CORNEA; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAOCULAR PRESSURE; IRIS; NEUROPROTECTION; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; RETINA; VITREOUS BODY;

EID: 0036217952     PISSN: 10570829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00061198-200204000-00009     Document Type: Article

References (28)

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5. Comparison of short- and long-term effects of betaxolol and timolol on human retinal circulation
6. Effects of antiglaucoma drugs on ocular hemodynamics in healthy volunteers
7. The susceptible optic nerve in glaucoma: Avenues for neuroprotection
8. In vivo and in vitro experiments show that betaxolol is a retinal neuroprotective agent
9. 2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration
10. Comparison of concentration-time profiles of levobunolol and timolol in anterior and posterior ocular tissues of albino rabbits
11. Distribution of topically administered drugs to the posterior segment of rabbit eye
12. Importance of the noncomeal absorption route in topical ophthalmic drug delivery
13. Disposition of timolol and inulin in the rabbit eye after corneal versus non-corneal absorption
14. Penetration of timolol into the rabbit eye. Measurements after ocular instillation and intravenous injection
15. Disposition of ophthalmic timolol in treated and untreated rabbit eyes. A multiple and single dose study
16. Active transport of beta-adrenergic blocking agents in the anterior uvea of albino rabbit
17. Penetration of timolol eye drops into human aqueous humor: The first hour
18. Absorption of ocular timolol: Drug concentrations and β-receptor binding activity in the aqueous humor of the treated and contralateral eye
19. Effect of topical timolol on the human retinal circulation
20. Effect of timolol maleate on the retinal circulation of human eyes with ocular hypertension
21. Beta-adrenergic blockers: Ocular penetration and binding to the uveal pigment
22. Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists
23. The contralateral reduction of intraocular pressure by timolol
24. Clinical pharmacokinetics of beta-adrenoreceptor blocking drugs
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26. Lack of metabolism of timolol by ocular tissues
27. Limbal microcirculation of the rat eye
28. Microvasculature of the rat optic nerve head