Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning

European Journal of Clinical Pharmacology

Volumn 58, Issue 1, 2002, Pages 41-44

  Dauer, Marc ^a   Schulze, Johannes ^a   Loher, Florian ^a   Endres, Stefan ^a   Eigler, Andreas ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

6 Mercaptopurine; 6 Thioguanine; Phenotyping; Thiopurine S methyltransferase

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; METHYLMERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; ERYTHROCYTE; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RADIOCHEMISTRY; RELIABILITY; THIN LAYER CHROMATOGRAPHY; VALIDATION PROCESS;

6-MERCAPTOPURINE; CARBON RADIOISOTOPES; CHROMATOGRAPHY, THIN LAYER; HUMANS; INDICATORS AND REAGENTS; METHYLTRANSFERASES; PHENOTYPE;

EID: 0036216723     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-001-0406-5     Document Type: Article

References (15)

1. Metabolism of thiopyrimidines and thiopurines
2. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
3. Thiopurine methyltransferase activity in American white subjects and black subjects
4. Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism
5. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient
6. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
7. Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine
8. Genetic polymorphism of thiopurine S-methyltransferase: Molecular mechanisms and clinical importance
9. High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: Quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methyl-mercaptopurine metabolites in a single sample
10. Thiopurine methyltransferase activity in a French population: H.P.L.C. assay conditions and effects of drugs and inhibitors
11. Thiopurine methyltransferase activity in the erythrocytes of adults and children: And HPLC-linked assay
12. Thiopurine S-methyltransferase activity in human erythrocytes: A new HPLC method using 6-thioguanine as substrate
13. Human erythrocyte thiopurine methyltransferase: Radiochemical microassay and biochemical properties
14. Interethnic difference in thiopurine methyltransferase activity
15. Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population