Inducing specific reactivity against B cells in mice by immunizing with an Fc fusion protein containing self-Igβ

Cancer Immunology, Immunotherapy

Volumn 51, Issue 3, 2002, Pages 145-152

  Sheu, Jim J C ^a   Huang, Janice ^a   Chang, Tse W ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Auto reactivity; B cell antigen receptor; Fc fusion protein; Surface antigen Ig (CD79b)

Indexed keywords

ANTISERUM; CELL SURFACE IMMUNOGLOBULIN; GLYCOPROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL ACTIVITY; CELL INTERACTION; CELL SURFACE; CONTROLLED STUDY; EXPRESSION VECTOR; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOMODULATION; IMMUNOREACTIVITY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD20; ANTIGENS, CD3; ANTIGENS, CD79; B-LYMPHOCYTES; BLOTTING, WESTERN; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC VECTORS; IMMUNOGLOBULIN G; LYMPHOCYTES; MICE; MICE, INBRED BALB C; PROTEIN BINDING; RATS; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRANSFECTION;

EID: 0036216563     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-001-0260-4     Document Type: Article

References (53)

1. Antigen presentation and self-nonself discrimination
2. Signaling antibodies in cancer therapy
3. Role of mu heavy chain in B cell development. I. Blocked B cell maturation but complete allelic exclusion in the absence of Ig alpha/beta
4. Breaking of B cell tolerance toward a highly conserved self-protein
5. Induction of cross-reactive antibodies against a self-protein by immunization with a modified self-protein containing a foreign T helper epitope
6. Therapeutic antibodies elicited by immunization against TNF-alpha
7. Possible mechanisms of autoantibody production
8. The complexity of signaling pathways activated by the BCR
9. Human HER-2/neu protein immunization circumvents tolerance to rat neu: A vaccine strategy for "self" tumor antigens
10. Expression and characterization of a DNase 1-Fc fusion enzyme
11. IgM rheumatoid factor autoantibody and immunoglobulin-producing precursor cells in the bone marrow of humans
12. The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene
13. Clinical trials of antibody therapy
14. Regulation of an early development checkpoint in the B cell pathway by Ig beta
15. B29: A member of the immunoglobulin gene superfamily exclusively expressed on B-lineage cells
16. Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans
17. Murine silver-induced autoimmunity: Silver shares induction of antinucleolar antibodies with mercury, but causes less activation of the immune system
18. Establishment and characterization of Balb/c lymphoma lines with B cell properties
19. Signaling function of the B cell antigen receptors
20. CD79a/CD79b heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain
21. Molecular mechanisms in B cell antigen receptor signaling
22. Expression of the Ig-associated heterodimer (mb-1 and B29) in Hodgkin's disease
23. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen
24. Direct evidence for functional self-protein/Ia-molecule complexes in vivo
25. Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c
26. The inability to process a self-peptide allows auto-reactive T cells to escape tolerance
27. Mutations in Igα (CD79a) result in a complete block in B cell development
28. + T cells
29. Determinant hierarchy: Shaping of the self-directed T cell repertoire, and induction of autoimmunity
30. The self-directed T cell repertoire against mouse lysozyme reflects the influence of the hierarchy of its own determinants and can be engaged by a foreign lysozyme
31. Recombinant human tumor necrosis factor receptor (p75) Fc fusion protein (TNFR:Fc) in rheumatoid arthritis
32. Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies
33. Architecture of the human B cell antigen receptors
34. Recombinant human tumor necrosis factor receptor Fc fusion protein therapy in kidney transplant recipients undergoing OKT3 induction therapy
35. Fetal liver pro-B and pre-B lymphocyte clones: Expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro
36. The role of Ig beta in precursor B cell transition and allelic exclusion
37. Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help
38. Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice
39. Antigen receptors on B lymphocytes
40. A sequence pattern common to T cell epitopes
41. Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells
42. Signal transduction by immunoglobulin is mediated through Igα and Igβ
43. Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodie
44. Generation and characterization of a single-gene encoded single-chain immunoglobulin-interleukin-2 fusion protein
45. Aberrant B cell development and immune response in mice with a compromised BCR complex
46. Monoclonal antibody therapy of B cell lymphoma: Signaling activity on tumor cells appears more important than recruitment of effectors
47. Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex
48. The B cell antigen receptor of the five immunoglobulin classes
49. Transcription and protein expression of mb-1 and B29 genes in human hematopoietic maglignancies and cell lines
50. Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of Bcl-2 protein
51. A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue
52. The development of anti-CD79 monoclonal antibodies for treatment of B cell neoplastic disease
53. IL-12 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice