New bone-seeking agent: Animal study of Tc-99m-incadronate

Annals of Nuclear Medicine

Volumn 16, Issue 1, 2002, Pages 55-59

  Shigematsu, Makoto ^a   Shiomi, Susumu ^a   Iwao, Hiroshi ^a   Ochi, Hironobu ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

99mTc; Bisphosphonate; Bone seeking agent; Incadronate; Rats

Indexed keywords

INCADRONIC ACID; NITROGEN; TECHNETIUM 99M; TIN CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BONE METASTASIS; BONE SCINTISCANNING; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; FEMUR; INTESTINE; KIDNEY; LIVER; MUSCLE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; SMALL INTESTINE; STOMACH; STRUCTURE ANALYSIS; URINALYSIS;

ANIMALS; BONE AND BONES; BONE NEOPLASMS; DIPHOSPHONATES; FEASIBILITY STUDIES; FEMALE; HYDROGEN-ION CONCENTRATION; KIDNEY; MODELS, MOLECULAR; MUSCLES; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SODIUM PERTECHNETATE TC 99M; TISSUE DISTRIBUTION; URINE; WHOLE-BODY COUNTING;

EID: 0036216053     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02995292     Document Type: Article

References (24)

1. Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
2. The effect of two diphosphonates on the resorption of mouse calvaria in vitro
3. Bisphosphonates - History and experimental basis
4. 2MBP-coated bone
5. Pyrophosphate and diphosphonates in skeletal metabolism
6. Structure-activity relationships of various bisphosphonates
7. Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat
8. Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo
9. Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy
10. Inhibitory effect of YM175 on bone resorption in vitro
11. Effect of YM175 on hypercalcemia induced by human squamous cell carcinoma of oral cavity
12. Studies on novel bone resorption inhibitors. I. Synthesis and pharmacological activities of aminomethylenebisphosphonate derivatives
13. The palliative management of skeletal metastases in prostate cancer: Use of boneseeking radionuclides and bisphosphonates
14. Tc-99m HMDP (hydroxymethylene diphosphonate): A radiopharmaceutical for skeletal and acute myocardial infarct imaging. I. Synthesis and distribution in animals
15. Technetium-99m-methylene diphosphonatea superior agent for skeletal imaging: Comparison with other technetium complexes
16. Rhenium-188 hydroxyethylidene diphosphonate: A new generator-produced radiotherapeutic drug of potential value for the treatment of bone metastases
17. The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear medicine
18. Tc-99m methylene diphosphonate versus Tc-99m pyrophosphate: Biologic and clinical comparison
19. The influence of two bone agents (Tc-99m pyrophosphate and Tc-99m methylenediphosphonate) on quantitative sacroiliac joint scintigraphy
20. Relapsing polychondritis diagnosed by Tc-99m MDP bone scintigraphy
21. Treatment of malignancy-associated hypercalcemia with YM175, a new bisphosphonate: Elevated threshold for parathyroid hormone secretion in hypercalcemic patients
22. Hypercalcemia due to parathyroid hormone-related protein produced by primary ovarian clear cell adenocarcinoma: Case report
23. The bisphosphonate incadronate for bone metastases of breast cancer
24. Bone-seeking properties of Tc-99m carbonyl diphosphonic acid and monohydroxy-methylene phosphonic acid: Concise communication