Alkalinization increases penetration of lidocaine across the human cornea

Journal of Cataract and Refractive Surgery

Volumn 28, Issue 4, 2002, Pages 692-696

  Fuchsjäger Mayrl, Gabriele ^a   Zehetmayer, Martin ^a,b   Plass, Herbert ^a   Turnheim, Klaus ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b Department of Ophthalmology ^*  (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; LIDOCAINE; MACROGOL;

ADULT; AGED; ALKALINIZATION; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; CORNEA PERFORATION; CORNEA PERMEABILITY; DIFFUSION; FEMALE; HUMAN; HUMAN TISSUE; LACRIMATION; MALE; NORMAL HUMAN; OSMOLARITY; PERFUSION; PH; PRIORITY JOURNAL; STEADY STATE;

ANESTHETICS, LOCAL; BIOLOGICAL TRANSPORT; BUFFERS; CORNEA; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; LIDOCAINE; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; PERMEABILITY; SODIUM ACETATE; SODIUM BICARBONATE; SOLUTIONS;

EID: 0036213296     PISSN: 08863350     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0886-3350(01)01233-0     Document Type: Article

References (29)

1. Topical anesthesia for small incision self-sealing cataract surgery; a prospective evaluation of the first 100 patients
2. Topical versus peribulbar anesthesia in clear corneal cataract surgery
3. Topical versus peribulbar anesthesia, without sedation, for clear corneal phacoemulsification
4. Comparison of 4 topical anesthetic agents for effect and corneal toxicity in rabbits
5. Effect of topical anesthetics on regeneration of corneal epithelium
6. Toxicity of xylocaine to rabbit corneal endothelium
7. The effects of intraocular lidocaine on the corneal endothelium
8. Topical anesthesia with pH-adjusted versus standard lidocaine 4% for clear corneal cataract surgery
9. Corneal preservation
10. Active transport of sodium as the source of electrical current in the short-circuited frog skin
11. Determination of the sodium transport pool in epithelia from tracer fluxes: A simplified approach
12. Corneal epithelial permeability after instillation of ophthalmic solutions containing local anaesthetics and preservatives
13. Effects of four penetration enhancers on corneal permeability of drugs in vitro
14. Corneal cytotoxicity of topically applied drugs, vehicles and preservatives
15. Enhancement of ocular drug penetration
16. Comparison of pain with pH-adjusted bupivacaine with hyaluronidase for peribulbar block
17. Topical bupivacaine and proparacaine: A comparison of toxicity, onset of action, and duration of action
18. Comparison of regional ophthalmic anesthesia produced by pH-adjusted 0.75% and 0.5% bupivacaine and 1% and 1.5% etidocaine, all with hyaluronidase
19. Preparation of pH-adjusted local anesthetics
20. The use of pH adjusted lignocaine in controlling operative pain in the day surgery unit: A prospective, randomised trial
21. Randomised control trial of pH buffered lignocaine with adrenaline in outpatient operations
22. The effect of needle gauge and lidocaine pH on pain during intradermal injection
23. The effect of alkalinisation of lignocaine on axillary brachial plexus anesthesia
24. Vehicle effects on ocular drug bioavailability. II: Evaluation of pilocarpine
25. Fluorophotometric measurement of the buffering action of human tears in vivo
26. The cornea