A new mouse model for autosomal recessive polycystic kidney disease

Genomics

Volumn 79, Issue 4, 2002, Pages 499-504

  Chittenden, Laura ^a   Lu, Xiaochen ^a   Cacheiro, Nestor L A ^c   Cain, K T ^d   Generoso, Walderico ^a   Bryda, Elizabeth C ^a   Stubbs, Lisa ^b  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^b University of Tennessee Oak Ridge Graduate School of Biomedical Sciences   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autosomal recessive polycystic kidney disease; Experimental animal models; Fluorescence in situ hybridization; Mice

Indexed keywords

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CHROMOSOME MAP; CHROMOSOME TRANSLOCATION 10; CHROMOSOME TRANSLOCATION 2; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENETIC COMPLEMENTATION; HISTOPATHOLOGY; KIDNEY POLYCYSTIC DISEASE; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALIA;

EID: 0036209095     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2002.6731     Document Type: Article

References (47)

1. Acquired cystic kidney disease
2. Polycystic kidney disease: I. Etiology and pathogenesis
3. A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16
4. Autosomal dominant polycystic kidney disease: Localization of the second gene to chromosome 4q13-q23
5. Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease
6. Evidence for a third genetic locus for autosomal dominant polycystic kidney disease
7. Possible locus for polycystic kidney disease on chromosome 2
8. Autosomal dominant polycystic kidney disease: Clues to pathogenesis
9. Polycystin: New aspects of structure, function, and regulation
10. Cystic renal diseases in children
11. Polycystic disease of kidney and liver presenting in childhood
12. Fine mapping of the autosomal recessive polycystic kidney disease locus (PKHD1) and the genes MUT, RDS, CSNK2 beta, and GSTA1 at 6p21.1-p12
13. A 1-Mb BAC/PAC-based physical map of the autosomal recessive polycystic kidney disease gene (PKHD1) region on chromosome 6
14. Analysis of chromosome 6p in Spanish families with recessive polycystic kidney disease
15. Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice
16. Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice
17. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene
18. Tg737 interacts with polycystin (PKD1) and proteins controlling epithelial polarity, EGF-R stability and cellular differentiation
19. Epidermal growth factor receptor expression is abnormal in murine polycystic kidney
20. Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease
21. Expression of the orpk disease gene during kidney development and maturation
22. Identification and genetic mapping of a new polycystic kidney disease on mouse chromosome 8
23. Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease
24. A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells
25. Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic
26. Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease
27. Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model
28. New mouse model for polycystic kidney disease with both recessive and dominant gene effects
29. The mouse polycystic kidney disease mutation (cpk) is located on proximal chromosome 12
30. Juvenile cystic kidneys (jck): A new mouse mutation which causes polycystic kidneys
31. A hereditary model of slowly progressive polycystic kidney disease in the mouse
32. Linkage analysis of two murine polycystic kidney disease genes, pcy and cpk
33. Genetic mapping of the polycystic kidney gene, pcy, on mouse chromosome 9
34. Chemical mutagenesis and fine-structure functional analysis of the mouse genome
35. Chlorambucil-induced mutations in mice recovered in homozygotes
36. Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice
37. Generation and characterization of heritable reciprocal translocations in mice
38. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16
39. Fine genetic map of mouse chromosome 10 around the polycystic kidney disease gene, jcpk, and ankyrin 3
40. Animal models of polycystic kidney disease
41. Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer
42. Cytogenetic analysis by chromosome painting using DOP-PCR amplified flow-sorted chromosomes
43. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein
44. Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease