Long-term suppression of viral replication despite low plasma saquinavir concentrations in the CHEESE study [1]

British Journal of Clinical Pharmacology

Volumn 53, Issue 2, 2002, Pages 211-212

  Van Heeswijk, Rolf P G ^a   Cohen Stuart, James W T ^b,c   Burger, David M ^d   Beijnen, Jos H ^a   Borleffs, Jan C C ^c   Hoetelmans, Richard M W ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; INDINAVIR; LAMIVUDINE; NELFINAVIR; PROTEINASE INHIBITOR; SAQUINAVIR; ZIDOVUDINE;

ACCURACY; CLINICAL TRIAL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; DRUG POTENCY; DRUG SENSITIVITY; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; MONONUCLEAR CELL; PRIORITY JOURNAL; TREATMENT OUTCOME; VIRUS LOAD; VIRUS REPLICATION;

DRUG MONITORING; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; SAQUINAVIR; TIME FACTORS; VIRUS REPLICATION;

EID: 0036207345     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2002.01530.x     Document Type: Letter

References (6)

1. The role of therapeutic drug monitoring in treatment of HIV infection
2. Randomized trial comparing saquinavir soft-gelatin capsules versus indinavir as part of triple therapy (CHEESE Study)
3. Simulatenous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir in human plasma by ion-pair high-performance liquid chromatography with ultraviolet detection
4. Differences in intracellular drug accumulation between the protease inhibitors
5. Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200-500 CD4+ cells per cubic millimeter
6. Therapeutic drug monitoring (TDM) of nelfinavir (NFV) and indinavir (IDV) in treatment naive patients improves therapeutic outcome after 1 year: Results from ATHENA