Cicatricial pemphigoid differs from bullous pemphigoid and pemphigoid gestationis regarding the fine specificity of autoantibodies to the BP180 NC16A domain

Journal of Dermatological Science

Volumn 28, Issue 1, 2002, Pages 68-75

  Kromminga, Arno ^a   Sitaru, Cassian ^b   Meyer, Jutta ^a   Arndt, Rüdiger ^a   Schmidt, Enno ^b   Christophers, Enno ^c   Bröcker, Eva B ^b   Zillikens, Detlef ^b  

^a Inst Immunol Pathol Molec Biol   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Autoantibodies; Autoantigen; Bullous skin disease; Dermal epidermal junction; Type XVII collagen

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; COLLAGEN TYPE 17; EPITOPE; IMMUNOGLOBULIN G ANTIBODY; POLYPEPTIDE;

AMINO TERMINAL SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; BULLOUS SKIN DISEASE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNOREACTIVITY; LICHEN PLANUS PEMPHIGOID; MUCOUS MEMBRANE PEMPHIGOID; PEMPHIGOID; PEMPHIGOID GESTATIONIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SERUM;

ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; DNA, COMPLEMENTARY; FEMALE; HUMANS; LICHEN PLANUS; PEMPHIGOID GESTATIONIS; PEMPHIGOID, BENIGN MUCOUS MEMBRANE; PEMPHIGOID, BULLOUS; PREGNANCY; PROTEIN STRUCTURE, TERTIARY;

EID: 0036206260     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(01)00144-X     Document Type: Article

References (21)

1. Acquired skin disease of hemidesmosomes
2. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180
3. A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen BP180
4. The majority of bullous pemphigoid and herpes gestationis serum samples react with the NC16a domain of the 180-kDa bullous pemphigoid antigen
5. A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid
6. Immunoreactivity of bullous pemphigoid (BP) autoantibodies against the NC16A and C-terminal domains of the 180 kDa BP antigen (BP180): Immunoblot analysis and enzyme-linked immunosorbent assay using BP180 recombinant proteins
7. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain
8. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies
9. IgG1 and IgG3 are the major immunoglobulin subclasses targeting epitopes within the NC16A domain of BP180 in pemphigoid gestationis
10. Molecular mapping of the major epitopes of BP180 recognized by herpes gestationis autoantibodies
11. Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180
12. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain
13. Analysis of antigens targeted by circulating IgG and IgA autoantibodies in 50 patients with cicatricial pemphigoid
14. IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180
15. A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone
16. A recombinant form of the human BP180 ectodomain forms a collagen-like homotrimeric complex
17. Patients with bullous pemphigoid and linear IgA disease show a dual IgA and IgG autoimmune response to BP180
18. Determination of nucleotide sequence in DNA
19. Cloning of the human type XVII collagen gene (COL17A1) and detection of novel mutations in generalized atrophic benign epidermolysis bullosa
20. Serological reactivity of recombinant 1D autoantigen and its expression in human thyroid and eye muscle tissue: A possible autoantigenic link in Graves' patients
21. Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease