Proliferating cell nuclear antigen assessed by a computer-assisted image analysis system in patients with chronic viral hepatitis and cirrhosis

Digestive and Liver Disease

Volumn 34, Issue 3, 2002, Pages 197-203

  Donato, M F ^a   Arosio, E ^a   Monti, V ^a   Fasani, P ^a   Prati, D ^a   Sangiovanni, A ^a   Ronchi, G ^a   Colombo, M ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Cirrhosis; Hepatocellular carcinoma; Proliferating cell nuclear antigen; Viral hepatitis

Indexed keywords

CYCLINE; LIVER ENZYME; MONOCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; AUTOMATION; CELL PROLIFERATION; CHRONIC HEPATITIS; COHORT ANALYSIS; COMPUTER ANALYSIS; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE SEVERITY; DYSPLASIA; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOPEROXIDASE STAINING; LINEAR REGRESSION ANALYSIS; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER INJURY; MALE; MULTIVARIATE ANALYSIS; NONHUMAN; PREVALENCE; SEX DIFFERENCE; VIRUS HEPATITIS;

EID: 0036206017     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1590-8658(02)80193-1     Document Type: Article

References (41)

1. Liver regeneration: Molecular mechanisms of growth control
2. Liver regeneration: Methods for monitoring and their applications
3. Clinical application of morphologic and immunocytochemical assessments of cell proliferation
4. Update on proliferation associated antibodies applicable to formalin-fixed paraffin embedded tissue and their clinical applications
5. Cyclin/PCNA is the auxiliary protein of DNA polymerase delta
6. Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division
7. Proliferating cell nuclear antigen (PCNA) immunolocalisation in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms
8. Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labeling for marking S phase cells in paraffin sections from animal and human tissue
9. Hepatocyte regeneration in acute fulminant and nonfulminant hepatitis: A study of proliferating cell nuclear antigen expression
10. PCNA/cyclin expression and BrdU uptake define different subpopulations in different cell lines
11. Control of mouse hepatocyte proliferation and ploidy by p53 and p53ser246 mutation in vivo
12. Increased risk of hepatocellular carcinoma development in patients with cirrhosis and with high hepatocellular proliferation
13. Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis
14. Hepatocyte proliferative activity in human liver cirrhosis
15. Hepatitis C virus carriers with persistently normal aminotransferase levels: Healthy people or true patients?
16. Hepatitis C virus (HCV)RNA in serum and peripheral blood mononuclear cells (PBMC) of blood donors with and without elevated aminotransferase activity
17. Classification of chronic viral hepatitis: A need for reassessment
18. Histological typing of tumors of the liver, biliary tract and pancreas. International histological classification of tumors number 20
19. Histological grading and staging of chronic hepatitis
20. Liver cell dysplasia: A premalignant condition
21. Prognostic significance of proliferating cell nuclear antigen (PCNA) expression in hepatocellular carcinoma
22. "Lifespan" of liver cells
23. Hepatocellular proliferation in patients with chronic hepatitis C and persistently normal or abnormal aminotransferase levels
24. Analysis of proliferating hepatocytes using a monoclonal antibody against proliferating cell nuclear antigen/cyclin in embedded tissues from various liver diseases fixed in formaldehyde
25. Proliferative activity of hepatocytes in chronic viral hepatitis as revealed by immunohistochemistry for proliferating cell nuclear antigen
26. Evaluation of hepatic proliferative activity in chronic liver diseases and hepatocellular carcinomas by proliferating cell nuclear antigen (PCNA) immunohistochemical staining of methanol-fixed tissues
27. Hepatocyte regeneration in chronic hepatitis C and interferon treatment: Analysis of immunohistological identification of proliferating cell nuclear antigen (PCNA)
28. Hepatocyte proliferative activity in chronic liver damage as assessed by the monoclonal antibody MIBI Ki67 in archival material: The role of etiology, disease activity, iron, and lipid peroxidation
29. Hepatocyte proliferation rate is a powerful parameter for predicting hepatocellular carcinoma development in liver cirrhosis
30. High rates of hepatocellular carcinoma in cirrhotic patients with high liver cell proliferative activity
31. Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice
32. The male preponderance in incidence of hepatocellular carcinoma in cirrhotic patients may depend on the higher DNA synthetic activity of cirrhotic tissue in men
33. Risk factors for hepatocellular carcinoma among patients with chronic liver disease
34. Imbalance between cytoproliferation and apoptosis in hepatitis C virus related chronic liver disease
35. Hepatocellular proliferation and development of hepatocellular carcinoma: A case-control study in chronic hepatitis C
36. Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma: A prospective study
37. A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma
38. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: A prospective study
39. Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: Matched case-control study, pathological analysis, and pathogenetic hypothesis
40. Histological features of cirrhosis with hepatitis C virus for prediction of hepatocellular carcinoma development; a prospective study
41. Preneoplastic cellular changes in liver