Phosphorylation of Vpr regulates HIV type 1 nuclear import and macrophage infection

AIDS Research and Human Retroviruses

Volumn 18, Issue 4, 2002, Pages 283-288

  Agostini, Isabelle ^a   Popov, Serguei ^b   Hao, Tang ^c   Li, Jian Hua ^a   Dubrovsky, Larisa ^a   Chaika, Oleg ^d   Chaika, Nina ^d   Lewis, Robert ^d   Bukrinsky, Michael ^a,e  

^a PICOWER INST FOR MEDICAL RESEARCH   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c Zycos Inc   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE; VPR PROTEIN;

ARTICLE; CELL ACTIVATION; CELL LINE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MUTATION; NUCLEAR IMPORT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; T LYMPHOCYTE; VIRION; VIRUS INFECTION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; CELL LINE; CELL NUCLEUS; GENE PRODUCTS, VPR; HIV-1; HUMANS; MACROPHAGES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; SEQUENCE HOMOLOGY, AMINO ACID; VIRUS REPLICATION;

EID: 0036205110     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922202753472856     Document Type: Article

References (29)

1. Human immunodeficiency virus vpr product is a virion-associated regulatory protein
2. Human immunodeficiency virus vpr gene encodes a virion-associated protein
3. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
4. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells
5. Viral protein R regulates nuclear import of the HIV-1 pre-integration complex
6. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection
7. Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex
8. Characterization of HIV-1 Vpr nuclear import: Analysis of signals and pathways
9. Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr
10. Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex
11. HIV-1 nuclear import: In search of a leader
12. In or out? Regulating nuclear transport
13. Phosphorylation of human immunodeficiency virus type 1 Vpr regulates cell cycle arrest
14. Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway: Replication is restricted at a postentry level
15. Human immunodeficiency virus type 1 Vpr protein is incorporated into the virion in significantly smaller amounts than Gag and is phosphorylated in infected cells
16. Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo
17. Construction and characterization of a stable full-length macrophage-tropic HIV type 1 molecular clone that directs the production of high titers of progeny virions
18. Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage
19. The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes
20. Heatshock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral pre-integration complex
21. Viral protein R of HIV-1
22. Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import
23. Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation
24. HIV-1 infection requires a functional integrase NLS
25. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells
26. HIV-1 genome nuclear import is mediated by a central DNA flap
27. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5
28. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex
29. Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr