Analysis of the effect of cannabinoids on GABAergic neurotransmission in the substantia nigra pars reticulata

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 4, 2002, Pages 326-334

  Wallmichrath, Ilka ^a   Szabo, Bela ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Brain slice; CB1 cannabinoid receptor; Extrapyramidal motor system; GABAergic neurotransmission; Patch clamp; Presynaptic receptor; Substantia nigra

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; MUSCIMOL; RIMONABANT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CAPSULA INTERNA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; GABAERGIC TRANSMISSION; GLOBUS PALLIDUS; INHIBITORY POSTSYNAPTIC POTENTIAL; NEUROTRANSMISSION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PATCH CLAMP; PRESYNAPTIC INHIBITION; RAT; SUBSTANTIA NIGRA;

ANIMALS; CANNABINOIDS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; GAMMA-AMINOBUTYRIC ACID; MORPHOLINES; NAPHTHALENES; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SUBSTANTIA NIGRA; SYNAPTIC TRANSMISSION;

EID: 0036203855     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-001-0520-z     Document Type: Article

References (47)

1. Synaptic organisation of the basal ganglia
2. Occlusion of the presynaptic action of cannabinoids in rat substantia nigra pars reticulata by cadmium
3. Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist
4. Marihuana
5. Immunohistochemical localization of the neural cannabinoid receptor in rat brain
6. Substantia nigra
7. Cannabinoid receptors and their endogenous agonists
8. 2 receptors
9. CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum
10. Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A
11. Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes
12. Loss of cannabinoid receptors in the substantia nigra in Huntington's disease
13. Nigral GABAergic mechanisms and EMG activity in rats: Differences between pars reticulata and pars compacta
14. Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
15. 1 receptor mRNA in neuronal subpopulations of rat striatum: A double-label in situ hybridization study
16. Pharmacology of cannabinoid receptors
17. Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles
18. 1 receptor-deficient mice
19. The role of the ventromedial thalamic nucleus in the catalepsy evoked from the substantia nigra pars reticulata in rats
20. Aminoalkylindole binding in rat cerebellum: Selective displacement by natural and synthetic cannabinoids
21. SR141716A is an inverse agonist at the human cannabinoid CB1 receptor
22. 3H]GABA in the substantia nigra of the rat: Relative contribution of GABA striato-pallido-nigral afferents and nigral GABA neurons
23. Cannabinoids decrease excitatory synaptic transmission and impair long-term depression in rat cerebellar Purkinje cells
24. Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors
25. Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry
26. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain
27. Localization of cannabinoid receptor mRNA in rat brain
28. Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata
29. Electrophysiological effects of a cannabinoid on neural activity in the globus pallidus
30. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons
31. Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals
32. 2 receptors
33. Pharmacology of cannabinoid receptor ligands
34. A synaptic currents in the rat substantia nigra pars reticulata
35. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
36. Role of the subthalamic nucleus in cannabinoid actions in the substantia nigra of the rat
37. Motor actions of cannabinoids in the basal ganglia output nuclei
38. Modulation of transmitter release via presynaptic cannabinoid receptors
39. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
40. Neurons of the substantia nigra reticulata receive a dense GABA-containing input from the globus pallidus of the rat
41. 2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro
42. Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons
43. Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum
44. Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulata
45. Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA
46. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
47. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses