The influence of dithiothreitol on DNA radiolysis in frozen aqueous solution: An EPR study

Radiation Physics and Chemistry

Volumn 64, Issue 2, 2002, Pages 107-113

  Ambroz, H B ^a   Kemp, T J ^b   Kornacka, E ^a   Przybytniak, G ^a  

^a INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Dithiothreitol; DNA radiolysis; EPR; Thiol

Indexed keywords

CRYOGENICS; DNA; PARAMAGNETIC RESONANCE; POSITIVE IONS; SOLUTIONS;

REDUCTIVE PATHWAYS;

RADIOLYSIS;

CATION; DITHIOTHREITOL; DNA; GUANINE; RADICAL; THIOL; THYMINE;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); DNA REPAIR; ELECTRON SPIN RESONANCE; RADIOLYSIS; TEMPERATURE;

EID: 0036201963     PISSN: 0969806X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-806X(01)00455-8     Document Type: Article

References (22)

1. The role of copper and iron ions in the γ-radiolysis of DNA. Part 1. EPR studies at cryogenic temperatures
2. Influence of oxygen on the repair of direct radiation damage to DNA by thiols in model systems
3. The effects of ionizing radiation on deoxyribonucleic acid. Part 5. The role of thiols in chemical repair
4. Tissue sulfhydryl groups
5. Protection of DNA by thiols
6. The effects of counter-ion condensation and co-ion depletion upon the rates of chemical repair of poly(U) radicals by thiols
7. Hydroxyl radical-induced hydrogen/deuterium exchange in amino acid carbon-hydrogen bonds
8. Effects of polyamines and thiols on the radiation sensitivity of bacterial transforming DNA
9. Influence of electron scavengers on the radical formation in thymidine-5'-monophosphate and DNA in frozen aqueous solution and glasses
10. Unstable intermediates. Part 178. The structure of intermediates formed in the radiolysis of thiols
11. DNA is not a molecular wire: Protein-like electron-transfer predicted for an extended Π-electron system
12. 'Chemical repair' in irradiated DNA solutions containing thiols and/or disulphides. Further evidence for disulphide radical anions acting as electron donors
13. Reactions of sulphonyl peroxyl radicals with DNA and its components: Hydrogen abstraction from the sugar backbone versus addition to pyrimidine double bonds
14. Pulse radiolysis of dithiothreitol
15. · from the reaction of cysteine, glutathione and penicillamine thiyl radicals with molecular oxygen
16. Protection or sensitization by thiols or ascorbate in irradiated solutions of DNA or deoxyguanosine
17. An electron spin resonance investigation of the structure and formation of sulfinyl radicals; reaction of peroxyl radicals with thiols
18. Electron movement through proteins and DNA
19. Reaction of cysteamine with individual DNA base radicals in γ-irradiated nucleotides at low temperature
20. Radioprotection of DNA by thiols: Relationship between the net charge on thiol and its ability to protect DNA
21. Aerobic radioprotection of pBR 322 by thiols: Effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals