An improved procedure for the large scale preparation of 5-bromo-2-hydroxynicotinic acid [5-bromo-3-carboxy-2(1H)-pyridone]

Synthesis

Volumn , Issue 4, 2002, Pages 528-532

  Haché, Bruno ^a   Duceppe, Jean Simon ^a   Beaulieu, Pierre L ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

Bromination; Bromine; Combinatorial chemistry; Electrophilic aromatic substitution; Hypobromite; Pyridine

Indexed keywords

BROMINE COMPOUNDS; SYNTHESIS (CHEMICAL);

BLEACH SOLUTION;

ALCOHOLS;

2 HYDROXYNICOTINIC ACID; 5 BROMO 2 HYDROXYNICOTINIC ACID [5 BROMO 3 CARBOXY 2(1H) PYRIDONE]; BLEACHING AGENT; BROMINE; BROMINE DERIVATIVE; NICOTINIC ACID DERIVATIVE; PYRIDONE DERIVATIVE; SODIUM BROMIDE; SODIUM HYPOBROMITE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BROMINATION; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; PH; REACTION ANALYSIS; TECHNIQUE;

EID: 0036201099     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-20959     Document Type: Article

References (17)