The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview

Journal of Nutrition

Volumn 132, Issue 3, 2002, Pages

  Mares Perlman, Julie A ^a   Millen, Amy E ^a   Ficek, Tara L ^a   Hankinson, Susan E ^b,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Carotenoids; Cataract; Lutein; Macular degeneration; Zeaxanthin

Indexed keywords

XANTHOPHYLL; ZEAXANTHIN;

CANCER; CARDIOVASCULAR DISEASE; CATARACT; CHRONIC DISEASE; CONFERENCE PAPER; EYE DISEASE; FOOD INTAKE; HUMAN; RETINA MACULA DEGENERATION;

EID: 0036200541     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.3.518s     Document Type: Conference Paper

References (91)

1. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas
2. Carotenoid content of fruits and vegetables: An evaluation of analytic data
3. Chromatographic analyses of xanthophylls in egg yolks from laying hens fed turf Bermuda grass (Cynodon dactylon) meal
4. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the Third National Health and Nutrition Examination Survey
5. Carotenoids in human blood and tissues
6. Dietary modification of human macular pigment density
7. A one year study of the macular pigment: The effect of 140 days of a lutein supplement
8. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density
9. Lutein and zeaxanthin in the eyes, serum and diet of human subjects
10. Factors that influence the bioavailability of xanthophylls
11. Carotenoid composition, concentrations, and relationships in various human organs
12. Concentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue
13. Analysis of macular pigment by HPLC: Retinal distribution and age study
14. Carotenoids in the human macula and whole retina
15. Distribution of lutein and zeaxanthin steroisomers in the human retina
16. Fat-soluble nutrient concentrations in different layers of human cataractous lens
17. Measurement of retinoids and carotenoids in breast adipose tissue and a comparison of concentrations in breast cancer cases and control subjects
18. Xanthophyll esters in human skin
19. Distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys
20. Biological control of primate macular pigment. Biochemical and densitometric studies
21. Stereochemistry of the macular carotenoids
22. Analysis of carotenoids in human and animal tissues
23. Distribution of macular pigment components, zeaxanthin, and lutein, in human retina
24. Lutein and zeaxanthin are associated with photoreceptors in the human retina
25. The first isolation of enantiomeric and mesozeaxanthin in nature
26. Macular pigment in donor eyes with and without AMD: A case-control study
27. Influence of lutein supplementation on macular pigment, assessed with two objective techniques
28. Sex differences in macular pigment optical density: Relation to plasma carotenoid concentrations and dietary patterns
29. Macular pigment density in monozygotic twins
30. The environment and disease: Association or causal?
31. Lutein improves visual function in some patients with retinal degeneration: A pilot study via the internet
32. Macular pigment and lutein supplementation in retinitis pigmentosa and usher syndrome
33. Oxygen radicals in the pathogenesis of cataracts-possibilities for therapeutic intervention
34. Diet and age-related macular degeneration
35. Antioxidant and prooxidant properties of carotenoids
36. Possible biologic mechanisms for a protective role of xanthophylls
37. Retinal sensitivity to damage from short wavelength light
38. Effects of repeated public exposures on the monkey macula
39. Ocular photosensitization
40. Light and risk for age-related eye diseases
41. Diet-related macular anomalies in monkeys
42. Light-induced photoreceptor apoptosis is correlated with dietary and retinal levels of 3R,3′R-zeaxanthin
43. Factors associated with age-related macular degeneration: An analysis of data from the First National Health and Nutrition Examination survey
44. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group
45. Risk factors for neovascular age-related macular degeneration
46. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population
47. Serum antioxidants and age-related macular degeneration in a population-based case-control study
48. Association of zinc and antioxidant nutrients with age-related maculopathy
49. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study
50. Essential fatty acids, plasma cholesterol, and fat-soluble vitamins in subjects with age-related maculopathy and matched control subjects
51. Long-term nutrient intake and early age-related nuclear lens opacities
52. Diet and nuclear lens opacities
53. Dietary antioxidants and incidence of age-related nuclear cataracts
54. A prospective study of carotenoid intake and risk of cataract extraction in U.S. men
55. A prospective study of carotenoid and vitamin A intake and risk of cataract extraction among U.S. women
56. Serum carotenoids and tocopherols and incidence of age-related nuclear cataract
57. Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers
58. Modulation of humoral and cell-mediated immune responses by dietary lutein in cats
59. Antioxidant activity of carotenoids: An electron-spin resonance study on betacarotene and lutein interaction with free radicals generated in a chemical system
60. Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: The structural aspects
61. Plasma xanthophylls carotenoids correlate inversely with indices of oxidative DNA damage and lipid peroxidation
62. Carotenoid mixture protect multimellar liposomes against oxidative damage: Synergistic effects of lycopene and lutein
63. Antimutagenicty of xanthophylls present in Aztec marigold (Tagetes erecta) against 1-nitropyrene
64. Antimutagenic activity of natural xanthophylls against aflatoxin B1 in Salmonella typhimurium
65. Dietary lutein but not astaxanthin or beta-carotene increases pim-1 gene expression in murine lyphocytes
66. Plasma antioxidant vitamins and carotenoids in five Japanese populations with varied mortality from gastric cancer
67. Carotenoids and colon cancer
68. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans
69. Non-invasive raman spectroscopic detection of carotenoids in human skin
70. A prospective study of the intake of vitamins C, E, and A and the risk of breast caner
71. A population-based case-control study of diet and breast cancer in Australia
72. Breast cancer and dietary and plasma concentrations of carotenoids and vitamin A
73. Dietary lutein from marigold extract inhibits mammary tumor development in BALB/c mice
74. Differential regulation of apoptosis in normal versus transformed mammary epithelium and retinoic acid
75. Premenopausal breast cancer risk and intake of vegetables, fruits and related nutrients
76. Relationships of serum carotenoids, retinol, α-tocopherol, and selenium with breast cancer risk: Results from a prospective study in Columbia, Missouri (United States)
77. Dietary carotenoids and Vitamins A, C, E and risk of breast cancer
78. Serum carotenoids and breast cancer
79. Correlations between carotenoid concentrations in serum and normal breast adipose tissue of women with benign breast tumor or breast cancer
80. Serum carotenoids and oxidative DNA damage in human lymphocytes
81. Interaction of peroxynitrite with carotenoids in human low density lipoproteins
82. The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells
83. Oxygenated carotenoid lutein and progression of early atherosclerosis: The Los Angeles atherosclerosis study
84. Associations of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis
85. Fruit and vegetable intake in relation to risk of ischemic stroke
86. β-Carotene, carotenoids and the prevention of coronary heart disease
87. In vivo assessment of retinal carotenoids: Macular pigment detection techniques and their impact on monitoring pigment status
88. Macular pigment optical density in a Midwestern sample
89. Sex differences in macular pigment optical density: Relation to plasma carotenoid concentrations and patterns
90. Macular pigment optical density in a Southwestern sample