KCO912: A potent and selective opener of ATP-dependent potassium (KATP) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 3, 2002, Pages 220-230

  Buchheit, Karl Heinz ^a,b,c   Manley, Paul W ^a,b,c   Quast, Ulrich ^a,b,c   Russ, Ulrich ^a,b,c   Mazzoni, Lazzaro ^a,b,c   Fozard, John R ^a,b,c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c European Network of National Information Centers   (France)

Author keywords

Airways hyperreactivity; Antibronchoconstrictor activity; Asthma; Potassium channel activation; Rhesus monkeys

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; 3,4 DIHYDRO 2,2 DIMETHYL 4 (2 OXO 1 PIPERIDINYL) 6 PENTAFLUOROETHYL 2H 1 BENZOPYRAN 3 OL; 3,4 DIHYDRO 3 HYDROXY 2,2 DIMETHYL 4 (2 OXO 1 PIPERIDINYL) N PHENYL 2H 1 BENZOPYRAN 6 SULPHONAMIDE; ADENOSINE TRIPHOSPHATE; BIMAKALIM; GLIBENCLAMIDE; KCO 912; LIPOPOLYSACCHARIDE; METHACHOLINE; POTASSIUM CHANNEL; RECEPTOR SUBUNIT; SALBUTAMOL; SULFONAMIDE; SULFONYLUREA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; AREA UNDER THE CURVE; ARTICLE; ASTHMA; BLOOD PRESSURE; BRONCHUS HYPERREACTIVITY; CARDIOVASCULAR EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENCY; DRUG SCREENING; DRUG SENSITIVITY; EFFUSION; GENETIC TRANSFECTION; GUINEA PIG; HEART RATE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; RADIOASSAY; RAT; RHESUS MONKEY; VASCULAR RING;

ADENOSINE TRIPHOSPHATE; ADMINISTRATION, INHALATION; ANIMALS; AORTA, THORACIC; ATP-BINDING CASSETTE TRANSPORTERS; BENZOPYRANS; BLOOD PRESSURE; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTION; CELL LINE; GUANIDINES; GUINEA PIGS; HEART RATE; INTUBATION, INTRATRACHEAL; MACACA MULATTA; MALE; PIPERIDINES; PORTAL VEIN; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; VASODILATOR AGENTS;

EID: 0036197263     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-001-0514-x     Document Type: Article

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