A novel role of RGS9: Inhibition of retinal guanylyl cyclase

Molecular and Cellular Biochemistry

Volumn 230, Issue 1-2, 2002, Pages 125-128

  Bondarenko, V A ^a   Yu, H ^a   Yamazaki, R K ^a   Yamazaki, A ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Phototransduction; Retinal guanylyl cyclase; RGS9

Indexed keywords

CYCLIC GMP; GUANOSINE TRIPHOSPHATE; GUANYLATE CYCLASE; PHOSPHODIESTERASE; PROTEIN SUBUNIT; RGS PROTEIN; TRANSDUCIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PHOTORECEPTOR; PHOTOTRANSDUCTION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; RETINA;

ANIMALS; GUANOSINE TRIPHOSPHATE; GUANYLATE CYCLASE; HYDROLYSIS; PHOTOTRANSDUCTION; RETINA; RGS PROTEINS;

EID: 0036196044     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014244107675     Document Type: Article

References (32)

1. Dark Mimic
2. Cyclic GMP-activated conductance of retinal photoreceptor cells
3. Amplification and kinetics of the activation steps in phototransduction
4. Transduction mechanisms of vertebrate and invertebrate photoreceptors
5. Flow of information in the light-triggered cyclic nucleotide cascade of vision
6. Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments
7. Activation mechanism of rod outer segment cyclic GMP phosphodiesterase-release of inhibitor by the GTP/GTP-binding protein
8. Molecular mechanism of GTP hydrolysis by bovine transducin: Pre-steady-state kinetic analysis
9. RGS9, a GTPase accelerator for phototransduction
10. A new family of G-protein regulators-the RGS proteins
11. RGS proteins: More than just GAPs for heterotrimrric G proteins
12. The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein β subunit
13. Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins
14. The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein
15. β5LGTPase-accelerating, protein complex control effector coupling, GTPase acceleration, protein folding, and stability
16. Calcium modulation of cyclic GMP synthesis in rat visual cells
17. Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions
18. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein
19. The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator
20. Guanylate cyclase from bovine rod outer segments: Solubilization, partial purification, and regulation by inorganic pyrophosphate
21. Preparation and characterization of guanylate cyclase from vertebrate rod photoreceptors
22. A possible role of RGS9 in phototransduction - A bridge between the cGMP phosphodiesterase system and the guanylyl cyclase system
23. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods
24. Immunocytochemical characterization of GCBP in mammalian retinas
25. The N-terminus of RGS9 is involved in its inhibition of retinal guanylate cyclase
26. 2+-binding proteins involves its dimerization
27. Light inhibition of bovine retinal rod guanylyl cyclase mediated by βγ-transducin
28. Phosphorylation of an inhibitory subunit of cGMP phosphodiesterase in Rana catesbiana rod photoreceptors - I. Characterization of the phosphorylation
29. Phosphorylation of an inhibitory subunit of cGMP phosphodiesterase in Rana catesbiana rod photoreceptors - II. A possible mechanism for the turnoff of cGMP phosphodiesterase without GTP hydrolysis
30. Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit of retinal cGMP phosphodiesterase - I. Identification of the kinase and its role in the turnoff of phosphodiesterase in vitro
31. Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit of retinal cGMP phosphodiesterase - II. Its role in the turnoff of phosphodiesterase in vivo
32. Possible stimulation of retinal rod recovery to dark state by cGMP release from a cGMP phosphodiesterase noncatalytic site