Conditional allele of mdm2 which encodes a p53 inhibitor

Genesis

Volumn 32, Issue 2, 2002, Pages 145-147

  Grier, Jason D ^a   Yan, Wen ^a   Lozano, Guillermina ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

ALLELE; ARTICLE; BLASTOCYST; CELL TRANSFORMATION; CHROMOSOME 12Q; DOUBLE MINUTE CHROMOSOME; ELECTROPORATION; EMBRYO DEATH; GENE AMPLIFICATION; GENE STRUCTURE; HOMOZYGOSITY; LETHAL MUTANT; NIDATION; NULL ALLELE; PRIORITY JOURNAL; PROGENY; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMALS; GENE EXPRESSION REGULATION; INTEGRASES; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; VIRAL PROTEINS;

EID: 0036195140     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.10066     Document Type: Article

References (13)

1. Targeted mutagenesis of the endogenous mouse Mis gene promoter: In vivo definition of genetic pathways of vertebrate sexual development
2. Molecular analysis and chromosomal mapping of amplification genes isolated from a transformed mouse 3T3 cell line
3. The loss of mdm2 induces p53 mediated apoptosis
4. An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2
5. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
6. T-cell specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site directed recombination
7. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
8. Mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts
9. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
10. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
11. The organization and expression of the mdm2 gene
12. Amplification of a gene encoding a p53-associated protein in human sarcomas
13. Oncoprotein MDM2 conceals the activation domain of tumor suppressor p53