Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity

Archives of Toxicology

Volumn 76, Issue 1, 2002, Pages 8-12

  Shimada, Hideaki ^a   Yamaguchi, Shizuka ^a   Murata, Hideyuki ^a   Otagiri, Masaki ^a   Imamura, Yorishige ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Acetohexamide; Androgen dependent metabolism; Cadmiun; Rat liver microsomes; Testicular toxicity

Indexed keywords

ACETOHEXAMIDE; ACETOHEXAMIDE REDUCTASE; ANDROGEN; ANTIDIABETIC AGENT; CADMIUM; ENZYME; KETONE; MICROSOME ENZYME; TESTOSTERONE PROPIONATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CASTRATION; CATALYSIS; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE; LIVER CYTOSOL; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TESTIS; TESTIS ATROPHY; TESTOSTERONE BLOOD LEVEL; TOXICITY;

ACETOHEXAMIDE; ALCOHOL OXIDOREDUCTASES; ANIMALS; CADMIUM; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MALE; MICROSOMES, LIVER; ORCHIECTOMY; RATS; RATS, WISTAR; TESTIS; TESTOSTERONE;

ANIMALIA;

EID: 0036192748     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-001-0313-7     Document Type: Article

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