P53 accumulation in favorable-histology Wilms tumor is associated with angiogenesis and clinically aggressive disease

Journal of Pediatric Surgery

Volumn 37, Issue 3, 2002, Pages 523-527

  Huang, Jianzhong ^a,b   Soffer, Samuel Z ^a,b   Kim, Eugene S ^a,b   Yokoi, Akiko ^a,b   Moore, James T ^a,b   McCrudden, Kimberly W ^a,b   Manley, Christina ^a,b   Middlesworth, William ^a,b   O'Toole, Kathleen ^a,b   Stolar, Charles ^a,b   Yamashiro, Darrell J ^a,b   Kandel, Jessica J ^a,b  

^a Columbia University ^*  (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Favorable histology; P53; Thrombospondin 1; Unfavorable histology; Wilms tumor

Indexed keywords

PROTEIN P53; THROMBOSPONDIN;

ANGIOGENESIS; CANCER INVASION; CONFERENCE PAPER; DNA DAMAGE; GENE LOCATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG METASTASIS; MISSENSE MUTATION; NEPHROBLASTOMA; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TUMOR SUPPRESSOR GENE;

EID: 0036191742     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1053/jpsu.2002.30858     Document Type: Conference Paper

References (11)

1. The treatment of Wilms tumor. Results of the National Wilms Tumor Studies
2. Treatment of children with stages II to IV anaplastic Wilms' tumor: A report from the national Wilms' tumor study group
3. Anaplastic Wilms' tumor, a subtpye displaying poor prognosis, harbours p53 gene mutations
4. Clinical implications of the p53 tumor-suppressor gene
5. Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer
6. p53 mutations in lung tumors: Relationship to putative susceptibility makers for carcinoma
7. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
8. Alterations in tumour suppressor gene p53 correlate with inhibition of thrombospondin-1 gene expression in colon cancer cells
9. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression
10. Metastasis correlates with production of vascular endothelial growth factor in a murine model of human Wilms' tumor
11. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours