Dioxin inhibition of estrogen-induced mouse uterine epithelial mitogenesis involves changes in cyclin and transforming growth factor-β expression

Toxicological Sciences

Volumn 66, Issue 1, 2002, Pages 62-68

  Buchanan, David L ^a,b,e   Ohsako, Seiichiro ^b,c   Tohyama, Chiharu ^b,c   Cooke, Paul S ^d   Iguchi, Taisen ^a,d  

^a NATIONAL INSTITUTES OF NATURAL SCIENCES   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Antiestrogen; Aryl hydrocarbon receptor; Cytokine; Estrogen; Ovariectomy; Proliferation; Uterus

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYCLIN A; CYCLIN B1; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLINE; ESTRADIOL; MESSENGER RNA; SESAME SEED OIL; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; BODY WEIGHT; CELL CYCLE S PHASE; CELL INTERACTION; CONTROLLED STUDY; DOSE RESPONSE; ENDOMETRIUM CELL; EPITHELIUM CELL; FEMALE; HYPEREMIA; IN VIVO STUDY; MITOGENESIS; MOUSE; NONHUMAN; OVARIECTOMY; PROTEIN EXPRESSION; REGULATORY MECHANISM; RIBONUCLEASE PROTECTION ASSAY; SIGNAL TRANSDUCTION; STROMA CELL; UTERUS WEIGHT; WEIGHT GAIN;

ANIMALIA; SESAMUM INDICUM;

EID: 0036191326     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/66.1.62     Document Type: Article

References (42)

1. TCDD-induced hyperplasia of the ureteral epithelium produces hydronephrosis in murine fetuses
2. Hormonal alterations in female rhesus monkeys fed a diet containing 2,3,7,8-tetrachlorodibenzo-p-dioxin
3. Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse uterus: Critical role of the aryl hydrocarbon receptor in stromal tissue
4. Tissue compartment-specific estrogen receptor-α participation in the mouse uterine epithelial secretory response
5. Stromal estrogen receptors (ER) mediate the mitogenic effect of estradiol on uterine epithelium
6. Restoration of normal morphology and estrogen responsiveness in cultured vaginal and uterine epithelia transplanted with stroma
7. Toxicology of dioxins and related compounds
8. Antiestrogen action of 2,3,7,8-tetrachlordibenzo-p-dioxin: Tissue-specific regulation of estrogen receptors in CD1 mice
9. Transforming growth factor-β (TGF-β)-induced down-regulation of cyclin A expression requires a functional TGF-β receptor complex. Characterization of chimeric and truncated type I and type II receptors
10. Interactive effects of estradiol and 2,3,7,8-tetrachlordibenzo-p-dioxin on hepatic cytochrome P-450 and mouse uterus
11. 1 cyclins and cyclin-dependent protein kinases
12. Estrogen-induced cyclin D1 and D3 gene expressions during mouse uterine-cell proliferation in vivo: Differential induction mechanism of cyclin D1 and D3
13. Bioaccumulation and occurrence of endocrine-disrupting chemicals (EDCs), persistent organic pollutants (POPs), and other organic compounds in fish and other organisms including humans
14. Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways
15. Cyclin A expression is under negative transcriptional control during the cell cycle
16. Long-term carcinogenesis studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexachlorodibenzo-p-dioxins
17. Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age
18. Autoinduction of transforming growth factor-β1 is mediated by the AP-1 complex
19. p27(Kipl) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells
20. Differential expression and regulation of cytokine genes in the mouse uterus
21. Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells
22. Cytokine gene expression during ontogeny in murine thymus on activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin
23. Identification of dioxin-responsive elements (DREs) in the 5′ regions of putative dioxin-inducible genes
24. Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis
25. Hypertrophy and hyperplasia in the mouse uterus after oestrogen treatment: An autoradiographic study
26. Oestriol, oestradiol-17β and the proliferation and death of uterine cells
27. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell-cycle arrest
28. 1 by p27Kipl
29. Molecular biology of the Ah receptor and its role in carcinogenesis
30. Chlorinated hydrocarbons: Estrogens and antiestrogens
31. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells
32. The transforming growth factor-β: Past, present, and future
33. Induction of ethoxyresorufin-O-deethylase and inhibition of glucocorticoid receptor binding in skin and liver of haired and hairless HRS/J mice by topically applied 2,3,7,8-tetrachlorodibenzo-p-dioxin
34. Evidence for the presence of macrophage migration inhibitory factor in murine reproductive organs, and early embryos
35. The Ah receptor: Genetics, structure, and function
36. Transforming growth factors β1, β2, and β 3 messenger RNA and protein expression in mouse uterus and vagina during estrogen-induced growth: A comparison to other estrogen-regulated genes
37. Involvement of macrophage migration inhibitory factor (MIF) in the mechanism of tumor cell growth
38. Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice
39. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on growth factor expression in the human breast cancer cell line MCF-7
40. Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: Modulation of hormone-induced cell cycle enzymes
41. Down-regulation of the cyclin A promoter by transforming growth factor-β1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein
42. Involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-β and apoptosis