CpG oligonucleotides: Novel regulators of osteoclast differentiation

FASEB Journal

Volumn 16, Issue 3, 2002, Pages 274-282

  Zou, W E I ^a   Schwartz, Harry ^a   Endres, Stefan ^b   Hartmann, Gunther ^b   Bar Shavit, Z V I ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Bone; Immunostimulatory oligodexynucleotide; M CSF; RANKL; TNF

Indexed keywords

COLONY STIMULATING FACTOR RECEPTOR; CYTOKINE; INTERLEUKIN 1BETA; OLIGONUCLEOTIDE; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; CYTOKINE RELEASE; MACROPHAGE; MALE; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM;

ACID PHOSPHATASE; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOENZYMES; KINETICS; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; OSTEOCLASTS; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; RNA, MESSENGER; STEM CELLS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE;

EID: 0036190385     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0586com     Document Type: Article

References (38)

1. Osteoclast generation
2. Control of osteoclast differentiation
3. The relationship of monocytic cells to the differentiation and resorption of bone
4. Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts
5. Regulation of tumor necrosis factor alpha transcription in macrophages: Involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B
6. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2
7. Requirement for NF-kappaB in osteoclast and B-cell development
8. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
9. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
10. A combination of osteoclast differentiation factor and macrophage-colony stimulating factor is sufficient for both human and mouse osteoclast formation in vitro
11. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor α-mediated shock
12. Mechanism and function of a newly identified CpG DNA motif in human primary cells
13. CpG DNA as a signal for growth, activation and maturation of human dendritic cells
14. Identification of CpG oligonucleotide sequences with high induction of IFN-α/-β in plasmacytoid dendritic cells
15. Now I know my CpGs
16. CpG motifs in bacterial DNA trigger direct B-cell activation
17. Immune activation by bacterial DNA: A new genetic code
18. A Toll-like receptor recognizes bacterial DNA
19. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
20. Antagonism of immunostimulatory CpG-oligodeoxymtdeotides by quinacrine, chloroquine, and structurally related compounds
21. Introduction to bone biology
22. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts
23. Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism
24. Dual effect of normal and stimulated macrophages and their conditioned media on target
25. Regulation of TNF-alpha release from bone marrow-derived macrophages by vitamin D
26. Extraction, purification, and analysis of messenger RNA from eukaryotic cells
27. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling
28. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
29. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
30. Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice
31. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
32. Recruitment of osteoclasts in the mandibular condyle of growing osteopetrotic (op/op) mice after a single injection of macrophage colony-stimulating factor
33. Retroviral-mediated gene transfer of CSF-1 into op/op stromal cells to correct defective in vitro osteoclastogenesis
34. Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor
35. Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation
36. Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival
37. Bacterially induced bone destruction: Mechanisms and misconceptions
38. The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides