Acyl specificity of phospholipases A2 and C in thrombin-stimulated human platelets

Platelets

Volumn 13, Issue 1, 2002, Pages 31-35

  Tsegaye, Yoseph ^a   Daasvatn, Knut Olav ^a   Holmsen, Holm ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; FATTY ACID; PHOSPHATIDIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; THROMBIN; UNSATURATED FATTY ACID;

ARTICLE; CELL ISOLATION; CELL LABELING; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION;

BLOOD PLATELETS; FATTY ACIDS, NONESTERIFIED; HUMANS; PHOSPHOLIPASE C; PHOSPHOLIPASES A; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 0036190204     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/09537100120111531     Document Type: Article

References (19)

1. Biochemistry of platelet activation
2. 2 in human platelets
3. 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides
4. An unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets
5. 2 of bone-derived macrophages
6. Esterification of 8,11,14-eicosatrienoate and arachidonate into alkylacyl and diacylglycerophosphocholine by vascular endothelial cells
7. Release of arachidonic acid from vascular endothelial cells: Fatty acyl specificity is observed with receptor-mediated agonists and with the calcium ionophore a23187 but not with melittin
8. 2)
9. 2
10. 2 from macrophages
11. Selective release of arachidonic acid from the phospholipids in human platelets in response to thrombin
12. Uptake, release and metabolism of docosahexenoic acid in human platelets and neutrophils
13. 3H]arachidonoyl species of phosphatidylinositol and phosphatidylcholine in thrombin-treated human platelets
14. Quantitative loss of individual eicosapentenoyl relative to arachidonoyl-containing phospholipids in thrombin-stimulated human platelets
15. Elevation of cyclic AMP decreases phosphoinositide turnover and thrombin-induced secretion in human platelets
16. Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated platelets
17. Diacyl glycerol elevations in control platelets are unaccompanied by pleckstrin phosphorylation. Implications for the role of diacylglycerol in platelet activation
18. Thin layer chromatography of polyphosphoinositides from platelet extracts: Interference by an unknown substance
19. + to secretory agents