On the use of nonparametric curves in phase I trials with low toxicity tolerance

Biometrics

Volumn 58, Issue 1, 2002, Pages 237-240

  Cheung, Ying Kuen ^a  

^a Columbia University ^*  (United States)

Author keywords

Bayesian nonparametric estimation; Continual reassessment method

Indexed keywords

BAYESIAN NONPARAMETRIC ESTIMATION; BAYESIAN NONPARAMETRICS; CLINICAL TRIAL; CONTINUAL REASSESSMENT METHOD; IN-PHASE; LOW TOXICITY; NON-PARAMETRIC ESTIMATES; NON-PARAMETRIC ESTIMATIONS; NONPARAMETRICS; PHASE I;

BIOMETRY; DOSE-RESPONSE RELATIONSHIP; TOXICITY;

ALGORITHM; ARTICLE; BAYES THEOREM; CLINICAL TRIAL; DOSE RESPONSE; EXPERIMENTAL DESIGN; HUMAN; METHODOLOGY; PARAMETRIC TEST; PHASE 1 CLINICAL TRIAL; TOXICITY TESTING;

EID: 0036188788     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.2002.00237.x     Document Type: Article

References (8)

1. Cancer phase I clinical trials: Efficient dose escalation with overdose control
2. Sequential designs for phase I clinical trials with late-onset toxicities
3. The continual reassessment method in cancer phase I clinical trials: A simulation study
4. A curve-free method for phase I clinical trials
5. Some practical improvements in the continual reassessment method for phase I studies
6. Continual reassessment method: A practical design for phase I clinical trials in cancer
7. Consistency of continual reassessment method under model misspecification
8. Current phase I/II designs: Are they adequate?