Production logistics and radionuclidic purity aspects of Sm for radionuclide therapy

Nuclear Medicine Communications

Volumn 23, Issue 1, 2002, Pages 83-89

  Ramamoorthy, N ^a   Saraswathy, P ^a   Das, M K ^a   Mehra, K S ^b   Ananthakrishnan, M ^b  

^a Board of Radiat/Isotope Technology   (India)

^b VECC Campus   (India)

Author keywords

Enriched Sm target; Natural Sm2O3 target; Radionuclide therapy; Radionuclidic impurities Eu and Eu; Re; Sm

Indexed keywords

EUROPIUM; EUROPIUM 154; EUROPIUM 155; RHENIUM 186; SAMARIUM 153; UNCLASSIFIED DRUG;

ARTICLE; BONE METASTASIS; BONE PAIN; CANCER PAIN; CANCER PALLIATIVE THERAPY; DRUG CONTAMINATION; DRUG INDICATION; DRUG PURITY; DRUG SYNTHESIS; HUMAN; NEUTRON ACTIVATION ANALYSIS; RADIOISOTOPE THERAPY; RADIOSURGERY; SYNOVECTOMY; TERMINAL CARE;

DRUG COMPOUNDING; EUROPIUM; NEUTRON ACTIVATION ANALYSIS; RADIOISOTOPES; RADIOPHARMACEUTICALS; SAMARIUM; SPECTROMETRY, GAMMA;

EID: 0036188358     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200201000-00013     Document Type: Article

References (25)

1. Ramamoorthy N, Saraswathy P. Radionuclides in medicine and research. In: Pant GS, ed. Radiation safety of unsealed sources. Mumbai: Himalaya Publishing House, 2000: 65-80.
2. Prabhakar G, Saraswathy P, Ramamoorthy N. Therapeutic radiopharmaceuticals. In: Ramamoorthy N, Shivarudrappa V, Bhelose AA, eds. Radiopharmaceuticals and hospital radiopharmacy practices. Mumbai: RPC/BRIT-DAE, 2000: 38-49.
3. 186Re labelled hydroxyapatite particles: potential radiopharmaceuticals for radiation synovectomy. J Nucl Med 1993; 34: 1536-1542.
4. Modder G. Radiosynoviorthesis. In: Warlich Druch und Verlagsges, Meckenheim, Germany 1995.
5. Maxon HR, Schroder LE, Hertzberg VS, Thomas SR, et al. Rhenium-186 (Sn) HEDP for treatment of painful osseous metastases: results of a double-blind crossover comparison with placebo. J Nucl Med 1991; 32: 1877-1881.
6. Goeckeler WF, Edward SB, Volkert WA, Holmes RA, Simon J, Wilson D. Skeletal localization of Sm-153 chelates: Potential therapeutic agents. J Nucl Med 1987; 28: 495-504.
7. Singh A, Holmes RA, Farhangi M, et al. Human pharmacokinetics of samarium-153 EDTMP in metastatic cancer. J Nucl Med 1989; 30: 1814-1818.
8. 153Sm-EDTMP in palliation of painful bone metastases. Ind J Nucl Med 2001; 16: 56-61.
9. 186Re(Sn)-HEDP for treatment of multiple metastatic foci in bone: human biodistribution and dosimetric studies. Radiology 1988; 166: 501-507.
10. 153Sm-EDTMP for metastatic bone pain palliation. In: Therapeutic applications of radiopharmaceuticals. IAEA-TEC DOC-1228. Vienna, IAEA, 2001: 236-246.
11. Coursey BM, ed. Radionuclides for bone palliation. Appl Radiat Isot 1998; 49: 275-356.
12. 186Re complexes of dimercaptosuccinic acid and hydroxy ethylidine diphosphonate. In: Modern trends in radiopharmaceuticals for diagnosis and therapy. IAEA-TECDOC-1029. Vienna: IAEA, 1998: 539-567.
13. Firestone R. Table of isotopes, 8th edition. Shirley VS, ed. New York: John Wiley & Sons Inc., 1996.
14. Reus U, Westmeier W, Warnecke I. Gamma-ray catalog. GSI Report 79-2. Darmstadt: Gesellschaft fur Schwerionenforschung, 1979.
15. Unni PR, Meera V, Pillai MRA, Ramamoorthy N. Development of indigenous products for radiation synovectomy. In: BARC Progress Report - 2000. Mumbai: Radiopharmaceuticals Division, BARC, 2001 (in press).
16. Arnikar HJ. Essentials of nuclear chemistry, 3rd edition. Mumbai: John Wiley Eastern, 1990.
17. United States Pharmacopoeia, 23rd edition, 1995; and British Pharmacopoeia, 1998.
18. Gunasekaran S, Nylla S, Ramamoorthy N. Pharmaco-kinetic studies and safety evaluation of radiopharmaceuticals in larger animal models. Final report of BRNS Project. BRNS Secretariat, BARC Mumbai, 2000.
19. 90Y generator. Radiochim Acta 2001; 89: 1-5.
20. Quadramet−, product pamphlet. Cis Bio International, France, 1997.
21. 90 Y silicate, package insert. Nycomed Amersham, UK.
22. 186 Re-S colloid, package insert. Cis Bio International, France.
23. Shah DH, Samuel AM, Rao RS. Thyroid cancer in an Indian perspective. Mumbai: Quest Publications, 1999.
24. Riccabona G. Dosimetry in radionuclide therapy. In: Therapeutic applications of radiopharmaceuticals. IAEA-TEC DOC-1228. Vienna: IAEA, 2001: 9-17.
25. 188Re-pentavalent rhenium dimercaptosuccinic acid complex. Nucl Med Commun 1993; 14: 197-203.