Macrophage and microglial cell immunoreactivity for PrPc in a random post-mortem population

Neuropathology and Applied Neurobiology

Volumn 28, Issue 1, 2002, Pages 79-82

  Esiri, M M ^a   Carter, J ^a   Ironside, J W ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORDANE; MONOCLONAL ANTIBODY; PRION PROTEIN;

ARTICLE; AUTOPSY; BASAL GANGLION; BRAIN CORTEX; BRAIN REGION; CADAVER; CEREBELLUM CORTEX; CREUTZFELDT JAKOB DISEASE; GRAY MATTER; HUMAN; IMMUNOREACTIVITY; LYMPHOID TISSUE; MACROPHAGE; MICROGLIA; NERVE FIBER; NEUROPATHOLOGY; PERIKARYON; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; THALAMUS;

HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICROGLIA; PRIONS; RANDOM ALLOCATION;

EID: 0036186839     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2002.00363.x     Document Type: Article

References (13)

1. Human muscle macrophages express beta-amyloid precursor and prion proteins and their mRNAs
2. Microglial expression of the prion protein
3. The mRNA encoding the scrapie agent protein is present in a variety of non-neuronal cells
4. Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans
5. Western blot detection of scrapie-associated fibril protein in tissues outside the central nervous system from preclinical scrapie-infected mice
6. Prion protein immunoreactivity in brain samples from an unselected autopsy population: Findings in 200 consecutive cases
7. Different levels of prion protein (PrPc) expression on hamster, mouse and human blood cells
8. Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease
9. PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice
10. The sequential development of abnormal prion protein accumulation in mice with Creutzfeldt-Jakob disease
11. Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations
12. Immunoreactivity of a synthetic pentadecapeptide corresponding to the N-terminal region of the scrapie prion protein
13. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie