Molecular orbital calculation for the model compounds of kainoid amino acids, agonists of excitatory amino acid receptors. Does the kainoid C4-substituent directly interact with the receptors?

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 5, 2002, Pages 1373-1379

  Hashimoto, Kimiko ^a,e   Matsumoto, Takatoshi ^b   Nakamura, Kensuke ^c   Ohwada, Shu ichi ^a   Ohuchi, Tatsuro ^a   Horikawa, Manabu ^a   Konno, Katsuhiro ^d   Shirahama, Haruhisa ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c Inst of Medicinal Molecular Design   (Japan)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^e RIKEN Center for Sustainable Resource Science   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RECEPTOR STIMULATING AGENT; AMPA RECEPTOR AGONIST; EXCITATORY AMINO ACID; EXCITATORY AMINO ACID RECEPTOR; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR AGONIST; AMINO ACID; KAINIC ACID;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CALCULATION; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTRON TRANSPORT; MOLECULAR MODEL; NERVE CELL EXCITABILITY; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN BINDING;

ALLOSTERIC SITE; AMINO ACIDS; EXCITATORY AMINO ACID AGONISTS; HUMANS; KAINIC ACID; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036185889     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00400-X     Document Type: Article

References (36)