Molecular properties of wild-type and mutant βIG-H3 proteins

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 3, 2002, Pages 656-661

  Kim, Jung Eun ^a   Park, Rang Woon ^a   Choi, Je Yong ^a   Bae, Yong Chul ^a   Kim, Ki San ^a   Joo, Choun Ki ^a   Kim, In San ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; COMPLEMENTARY DNA; MUTANT PROTEIN; N ACETYL BETA GLUCOSAMINIDASE; PROTEIN; PROTEIN BETA IG H3; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CHROMOSOME 5Q; CONTROLLED STUDY; CORNEA DYSTROPHY; CORNEA EPITHELIUM; CROSS LINKING; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ESCHERICHIA COLI; EXPRESSION VECTOR; EXTRACELLULAR MATRIX; GEL ELECTROPHORESIS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN STRUCTURE;

ACETYLGLUCOSAMINIDASE; CELL ADHESION; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 5; COLLAGEN TYPE I; CORNEAL DYSTROPHIES, HEREDITARY; EPITHELIUM, CORNEAL; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; GENE EXPRESSION; HUMANS; LAMININ; NEOPLASM PROTEINS; POINT MUTATION; RECOMBINANT PROTEINS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036184212     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. cDNA cloning and sequence analysis of βig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-β
2. Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-β-induced gene, βig-h3
3. Kerato-epithelin mutations in four 5q31-linked corneal dystrophies
4. Advances in the molecular genetics of corneal dystrophies
5. On the role of kerato-epithelin in the pathogenesis of 5q31-linked corneal dystrophies
6. Immunolocalization of βig-h3 protein in 5q31-linked corneal dystrophies and normal corneas
7. Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interact simultaneously with both the CBF-A and CBF-C subunit to form a heterotrimeric CBF molecule
8. Overexpression of the transforming growth factor-b-inducible gene βig-h3 in anterior polar cataracts
9. An SV40-immortalized human corneal epithelial cell line and its characterization
10. Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila
11. Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/βig-h3) that binds to collagen
12. Amyloid and non-amyloid forms of 5q31-linked corneal dystrophy resulting from keratoepithelin mutations at Arg-124 are associated with abnormal turnover of the protein
13. βig-h3 is synthesized by corneal epithelium and perhaps endothelium in Fuchs' dystrophic corneas
14. In vitro creation of amyloid fibrils from native and Arg124Cys mutated βig-h3 peptides, and its relevance for lattice corneal amyloid dystrophy type I
15. BIGH3 exon 14 mutations lead to intermediate type I/IIIA of lattice corneal dystrophies
16. Beta-ig, molecular cloning and in situ hybridization in corneal tissues
17. Recent advances in corneal stromal dystrophies
18. Microfibrillar protein and phospholipid in granular corneal dystrophy
19. Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies