PTEN mutation is rare in chondrosarcoma

Diagnostic Molecular Pathology

Volumn 11, Issue 1, 2002, Pages 22-26

  Lin, Chuzhao ^a   Meitner, Patricia A ^a   Terek, Richard M ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Bone tumor; Chondrosarcoma; PTEN; Tumor suppressor gene

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; BONE TUMOR; CHONDROSARCOMA; CHROMOSOMAL LOCALIZATION; CHROMOSOME 10Q; ENHANCER REGION; GENE MUTATION; GENETIC POLYMORPHISM; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

BONE NEOPLASMS; CHONDROSARCOMA; DNA, NEOPLASM; HUMANS; MEMBRANE PROTEINS; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0036183251     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200203000-00005     Document Type: Article

References (24)

1. Chondrosarcoma including spindle-cell (dedifferentiated) and myxoid chondrosarcoma; Mesenchymal chondrosarcoma
2. Oncogene alterations in primary, recurrent, and metastatic human bone tumors
3. p53 mutations in chondrosarcoma
4. Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues
5. Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas
6. Frequent loss of heterozygosity for markers on chromosome arm 10q in chondrosarcomas
7. Chromosomal rearrangements in chondromatous tumors
8. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
9. Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
10. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecologic malignancies
11. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
12. Synthesis of chondrocytic keratan sulphate-containing proteoglycans by human chondrosarcoma cells in long-term cell culture
13. Extraction and isolation of mRNA from adult articular cartilage
14. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
15. RNA isolation from cartilage using density gradient centrifugation in cesium trifluoroacetate: An RNA preparation technique effective in the presence of high proteoglycan content
16. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
17. PTEN/MMAC1 mutations in endometrial cancers
18. Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma
19. Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma
20. Molecular analysis of a myxoid chondrosarcoma with rearrangements of chromosomes 10 and 22
21. Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q
22. Functional evaluation of p53 and PTEN gene mutations in gliomas
23. Genetic profile of gliosarcomas
24. Functional evaluation of PTEN missense mutations using in vitro phosphoinosiride phosphatase assay