Turning on the Arp2/3 complex at atomic resolution

Structure

Volumn 10, Issue 2, 2002, Pages 131-135

  Borths, Elizabeth L ^a   Welch, Matthew D ^b  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; PROTEIN SUBUNIT;

CATTLE; CRYSTAL STRUCTURE; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; REVIEW; X RAY CRYSTALLOGRAPHY;

ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 3; ACTINS; ADENOSINE TRIPHOSPHATE; ANIMALS; CYTOSKELETAL PROTEINS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

BOS TAURUS; BOVINAE;

EID: 0036180316     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00712-8     Document Type: Review

References (27)

1. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells
2. Structure and function of the Arp2/3 complex
3. Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose
4. Actin polymerization is induced by the Arp2/3 protein complex at the surface of Listeria monocytogenes
5. Sequences, structural models, and cellular localization of the actin-related proteins Arp2 and Arp3 from Acanthamoeba
6. Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins
7. Cytoskeleton: Actin and endocytosis - No longer the weakest link
8. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
9. The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of actin filaments
10. Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy
11. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins
12. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly
13. Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia
14. Structure of Arp2/3 complex in its activated state and in actin filament branch junctions
15. Crystal structure of Arp2/3 complex
16. Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba
17. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
18. Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub
19. A mutant of Arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast
20. Genetic dissection of the budding yeast Arp2/3 complex: A comparison of the in vivo and structural roles of individual subunits
21. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity
22. Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments
23. Activation of Arp2/3 complex by Wiskott-Aldrich Syndrome protein is linked to enhanced binding of ATP to Arp2
24. Activation of the Arp2/3 complex by the Listeria ActA protein. ActA binds two actin monomers and three subunits of the Arp2/3 complex
25. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP
26. Different WASP family proteins stimulate different Arp2/3 complex- dependent actin-nucleating activities
27. Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex