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Volumn 30, Issue 3, 2002, Pages 225-230

Structural characterization of in vivo rat glutathione adducts and a hydroxylated metabolite of simvastatin hydroxy acid

(3) Subramanian, Raju a Fang, Xiaojun a Prueksaritanont, Thomayant a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3',5'BETA,6'BETA DIHYDROTRIOL SIMVASTATIN HYDROXY ACID; 5'BETA,6'BETA DIHYDROXY 4'ALPHA GLUTATHIONE SIMVASTATIN HYDROXY ACID; DRUG METABOLITE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; SIMVASTATIN; SIMVASTATIN HYDROXY ACID; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BILE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DOG; DRUG CONJUGATION; DRUG HYDROLYSIS; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS;

ANIMALS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; GLUTATHIONE; HYDROXYLATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SCINTILLATION COUNTING; SIMVASTATIN; SPECIES SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0036179578 PISSN: 00909556 EISSN: None Source Type: Journal
DOI: 10.1124/dmd.30.3.225 Document Type: Article

Times cited : (9)

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