Synthesis of variously 9,9-dialkylated octahydropyrimido [3,4-a]-s-triazines with potential antifungal activity

Farmaco

Volumn 57, Issue 2, 2002, Pages 109-116

  Ghaib, Amar ^a   Ménager, Sabine ^a   Vérité, Philippe ^a   Lafont, Olivier ^a  

^a UNIVERSITÉ DE ROUEN   (France)

Author keywords

9,9 Dialkyloctahydropyrimido 3,4 a s triazines; Antifungal agents; Ethyl 2,2 dialkylcyanoacetates; Iminodimethylation

Indexed keywords

6 AMINOPYRIMIDINE 2,4(3H,5H) DIONE; 9 BUTYL 9 ETHYL 6,8 DIOXO 3 (3 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9 BUTYL 9 ETHYL 6,8 DIOXO 3 (4 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9 BUTYL 9 ETHYL 6,8 DIOXO 3 PHENYL 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9 ETHYL 9 PROPYL 6,8 DIOXO 3 (2 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9 ETHYL 9 PROPYL 6,8 DIOXO 3 (3 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9 ETHYL 9 PROPYL 6,8 DIOXO 3 PHENYL 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIBUTYL 6,8 DIOXO 3 (2 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIBUTYL 6,8 DIOXO 3 (3 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIBUTYL 6,8 DIOXO 3 (3 TRIFLUOROMETHYLPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIBUTYL 6,8 DIOXO 3 (4 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIBUTYL 6,8 DIOXO 3 (4 TRIFLUOROMETHYLPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIBUTYL 6,8 DIOXO 3 PHENYL 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIPROPYL 6,8 DIOXO 3 (2 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIPROPYL 6,8 DIOXO 3 (2 TRIFLUOROMETHYLPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIPROPYL 6,8 DIOXO 3 (2,4 DICHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIPROPYL 6,8 DIOXO 3 (3 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIPROPYL 6,8 DIOXO 3 (4 CHLOROPHENYL) 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; 9,9 DIPROPYL 6,8 DIOXO 3 PHENYL 2,3,4,5,6,7,8,9 OCTAHYDROPYRIMIDO[3,4 A]TRIAZINE; ACETIC ACID DERIVATIVE; ANILINE DERIVATIVE; FORMALDEHYDE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UREA;

AMINOMETHYLATION; ANTIFUNGAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; IMINODIMETHYLATION; IN VITRO STUDY; MICROSPORUM CANIS; NONHUMAN;

EID: 0036176511     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01181-8     Document Type: Article

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