Pharmacophore determination of a gp120 C terminal-derived anti-HIV peptide construct interfering with membrane fusion suggesting that processing of the gp120 C terminus is a prelude to fusion

AIDS Research and Human Retroviruses

Volumn 18, Issue 3, 2002, Pages 201-206

  Barbouche, R ^a,b   Feyfant, E ^a   Belhaj, B ^a,b   Fenouillet, Emmanuel ^a  

^a CNRS   (France)

^b UNIVERSITY OF MONASTIR   (Tunisia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ANTIGEN; ENVELOPE PROTEIN; GLYCOPROTEIN GP 120; LYMPHOCYTE ANTIGEN; PEPTIDE; PROTEINASE; VIRUS ENZYME;

ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FUSION; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; LYMPHOCYTE; MEMBRANE FUSION; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANTIGENS, CD26; ANTIGENS, CD4; ANTIVIRAL AGENTS; HIV ENVELOPE PROTEIN GP120; HUMANS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; PEPTIDES; RECEPTORS, CXCR4;

EID: 0036176287     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/08892220252781257     Document Type: Article

References (26)

1. Maturation and assembly of retroviral glycoproteins
2. Immunological analysis of human immunodeficiency virus type 1 envelope glycoprotein proteolytic cleavage
3. Improved antigenicity of the HIV env protein by cleavage site removal
4. Unwelcomed guests with master keys: How HIV uses chemokine receptors for cellular entry
5. The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: A possible function in viral fusion?
6. T cell activation antigen CD26 as a cofactor for entry of HIV in CD4+ cells
7. Identification of the U937 membrane-associated proteinase interacting with the V3 loop of HIV-1 gp120 as cathepsin G
8. HIV entry and its inhibition
9. Inhibition of furin mediated cleavage activation of human immunodeficiency virus type 1 glycoprotein gp160
10. The convertase furin and PC1 can both cleave the human immunodeficiency virus type 1 envelope glycoprotein gp160 into gp120 and gp41
11. An anti-HIV peptide construct derived from the cleavage region of Env acts on Env fusogenicity through the presence of a functional cleavage sequence
12. An anti-human immunodeficiency virus multiple antigen peptide encompassing the cleavage region of the Env precursor interferes with membrane fusion at a post-CD4 binding step
13. Mutational analysis of the human immunodeficiency virus type 1 env gene product proteolytic cleavage site
14. Analysis of the cleavage of the human immunodeficiency virus type 1 glycoprotein
15. The catalytic activity of protein disulfide isomerase is involved in human immunodeficiency virus envelope-mediated membrane fusion after CD4 binding
16. Relationships between the anti-HIV V3-derived peptide SPC3 and lymphocyte membrane properties involved in virus entry: SPC3 interferes with CXCR4
17. Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells
18. Role of hemagglutinin cleavage for the pathogenicity of influenza virus
19. Synthetic peptides and anti-peptide antibodies as probes to study interdomain interactions involved in virus assembly: The envelope of the human immunodeficiency virus (HIV-1)
20. Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein
21. Mechanism of anti-HIV activity of negatively charged albumins: Biomolecular interaction with the HIV-1 envelope protein gp120
22. Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate
23. Role of HIV-1 envelope V3 loop cleavage in cell tropism
24. Inhibition of HIV-1 in cell culture by synthetic humate analogues derived from hydroquinone: Mechanism of inhibition
25. Tryptase TL2 in the membrane of human T4+ lymphocytes is a novel binding protein of the V3 domain of HIV-1 envelope glycoprotein gp120
26. The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin