Pharmacokinetic overview of Ortho Evra™/Evra™

Fertility and Sterility

Volumn 77, Issue SUPPL. 2, 2002, Pages 3-12

  Abrams, Larry S ^a   Skee, Donna ^a   Natarajan, Jaya ^a   Wong, Frankie A ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Contraception; Contraceptive patch; Ethinyl estradiol; Evra ; Norelgestromin; Ortho Evra ; Pharmacokinetics; Transdermal contraception

Indexed keywords

DRUG METABOLITE; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS NORGESTIMATE; NORELGESTROMIN; NORGESTIMATE; TETRACYCLINE; UNCLASSIFIED DRUG;

CONTRACEPTIVE DEVICE; CONTRACEPTIVE PATCH; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; EXERCISE; HEAT; HUMAN; HUMIDITY; PRIORITY JOURNAL; REVIEW; WATER IMMERSION;

EID: 0036175435     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0015-0282(01)03261-7     Document Type: Review

References (17)

1. Efficacy and safety of a monophasic and a triphasic oral contraceptive containing norgestimate
2. Pharmacologic and pharmacokinetic characteristics of norgestimate and its metabolites
3. Bioavailability of 17-deacetylnorgestimate (17D-NGM) and ethinyl estradiol (EE) from a contraceptive patch
4. Determination of norgestimate and its metabolites in human serum using high-performance liquid chromatography with tandem mass spectrometric detection
5. Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches
6. Pharmacokinetics of a contraceptive patch (EVRA™/ORTHO EVRA™) containing norelgestromin and ethinyl estradiol at four application sites
7. Sex-hormone-binding globulin
8. Clinical and biochemical investigations of a variable-dose combined type oral contraceptive
9. Relative binding affinity of norgestimate and other progestins for human sex hormone-binding globulin
10. Dose proportionality study of a contraceptive patch
11. Pharmacokinetics of a contraceptive patch
12. Multiple-dose pharmacokinetics of a contraceptive patch in healthy women participants
13. Transdermal contraception: Evaluation of three transdermal norelgestromin/ethinyl estradiol doses in a randomized, multicenter, dose-response study
14. Pharmacokinetics of norelgestromin and ethinyl estradiol delivered by a contraceptive patch (Ortho Evra™/Evra™) under conditions of heat, humidity, and exercise
15. Oral contraceptive drug interactions: Important considerations
16. Tetracycline HCL does not affect the pharmacokinetics of a contraceptive patch