Oxygen species in the microvascular environment: Regulation of vascular tone and the development of hypertension

Nephrology Dialysis Transplantation

Volumn 17, Issue 2, 2002, Pages 216-221

  Rathaus, Mauro ^a   Bernheim, Jacques ^a  

^a MEIR MEDICAL CENTER   (Israel)

Author keywords

Endothelium; Hydrogen peroxide; Hypertension; Nitric oxide; Oxydril radical; Superoxide

Indexed keywords

ALLOPURINOL; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ANTIOXIDANT; ASCORBIC ACID; CALCIUM ANTAGONIST; COLECALCIFEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN RECEPTOR ANTAGONIST; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; FREE RADICAL; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LOSARTAN; NITRIC OXIDE; OXIPURINOL; OXYGEN RADICAL; PEROXIDE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; VASOCONSTRICTOR AGENT; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HYPERPOLARIZATION; HYPERTENSION; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0036174762     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/17.2.216     Document Type: Article

References (92)

1. Endothelial dysfunction in hypertension
2. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries
3. Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery
4. Mesenteric arterial function in vitro in three models of experimental hypertension
5. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension
6. Abnormal endothelium dependent vascular relaxation in patients with essential hypertension
7. Impaired endothelium-dependent vasodilation in patients with essential hypertension
8. Vasodilatation to acetylcholine in primary and secondary forms of human hypertension
9. Endothelium-dependent forearm vasodilation is reduced in normotensive subjects with familial history of hypertension
10. Measures of endothelial function as an endpoint in hypertension
11. 2α in essential hypertension
12. Impaired nitric oxide- and prostaglandin-mediated responses to flow in resistance arteries of hypertensive rats
13. Selective defect in nitric oxide synthesis may explain the impaired endothelium-dependent vasodilation in patients with essential hypertension
14. Endothelium-derived free radicals: For worse and for better
15. Important role of endothelium-derived hyperpolarizing factor in shear stress-induced endothelium-dependent relaxations in the rat mesenteric artery
16. Comparison of the effects of nitric oxide synthase, guanylate cyclase and potassium channel inhibition on vascular contractions in vitro in the rat
17. An indirect influence of phenylephrine on the release of endothelium-derived vasodilators in rat small mesenteric artery
18. Reduced basal NO-mediated dilation and decreased endothelial NO-synthase expression in coronary vessels of spontaneously hypertensive rats
19. Alterations of nitric oxide synthase expression with aging and hypertension in rats
20. Absence of linkage for 'endothelial' nitric oxide synthase locus to blood pressure in Dahl rats
21. Impairment and restoration of nitric oxide-dependent vasodilation in cardiovascular disease
22. Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension
23. Endothelium-derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats
24. Antihypertensive treatment improves endothelium-dependent hyperpolarization in the mesenteric artery of spontaneously hypertensive rats
25. + channels in mesenteric arteries from spontaneously hypertensive rats by prolonged treatment with cholecalciferol
26. Prolonged blockade of endothelin ET(A) receptors decreases vascular reactivity in the aorta of spontaneously hypertensive rats in vitro
27. Does superoxide underlie the pathogenesis of hypertension?
28. Nitric oxide, superoxide and peroxinitrite: The goal, the bad, and the ugly
29. Superoxide anions and hypoxia inactive endothelium-derived relaxing factors
30. Nitric oxide and reactive oxygen species in vascular injury
31. NAD(P)H oxidase. Role in cardiovascular biology and disease
32. Hypercholesterolemia increases endothelial superoxide anion production
33. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
34. Endothelial dysfunction in cardiovascular diseases. The role of oxidant stress
35. NADH oxidase activity of human xanthine oxidoreductase - Generation of superoxide anion
36. Generation of superoxide by purified brain nitric oxide synthase
37. 2+/ calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase
38. Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
39. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice
40. -•), superoxide dismutases and related matters
41. The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase
42. Extracellular superoxide dismutase: A regulator of nitric oxide bioavailability
43. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats: Hydroethidine microfluorography
44. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats
45. Oxidative stress in the Dahl hypertensive rat
46. Manifestation of oxidative stress in the pathogenesis of arterial hypertension in ISIAH rats
47. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: Role of nitric oxide
48. Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt
49. Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: Evidence for an involvement of protein kinase
50. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats
51. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats
52. Decreased superoxide dismutase activity in increased superoxide anion production in cardiac hypertrophy of spontaneously hypertensive rats
53. Regional distribution of superoxide dismutate in the brain and myocardium of the stroke-prone spontaneously hypertensive rat
54. Effects of antihypertensive drugs on antioxidant enzyme activities and renal function in stroke-prone spontaneously hypertensive rats
55. Flow-dependent arteriolar dilation in normotensive rats fed low- or high-salt diets
56. High Na intake decreases pressure-induced (myogenic) tone and flow-induced dilation in resistance arteries from hypertensive rats
57. Structure and function of small arteries in salt-induced hypertension: Effects of chronic endothelin-subtype-A-receptor blockade
58. Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosterone-salt hypertensive rats
59. Reactive oxygen species may contribute to reduced endothelium-dependent dilation in rats fed high salt
60. Increased superoxide anion production in humans: A possible mechanism for the pathogenesis of hypertension
61. Status of free radicals and their scavenging enzymes in pregnancy induced hypertension
62. Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H in the SHR aorta
63. Indomethacin improves the impaired endothelium-dependent relaxations in small mesenteric arteries of the spontaneously hypertensive rat
64. A mechanism of oxygen free radical production in the Dahl hypertensive rat
65. Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved
66. The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats
67. Plasma hydrogen peroxide production in human essential hypertension: Role of heredity, gender, and ethnicity
68. Exacerbation of atherosclerosis by hypertension. Potential mechanisms and clinical implications
69. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients
70. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension
71. Potentiation of nitric oxide-mediated vasorelaxation by xanthine oxidase inhibitors
72. Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes
73. Xanthine oxidase inhibition with oxypurinol improves endothelial vasodilator function in hypercholesterolemic but not in hypertensive patients
74. Captopril improves impaired endothelium-dependent vasodilatation in hypertensive patients
75. Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients
76. The effect of antihypertensive therapy on responsiveness to local intra-arterial N G-mono-methyl-L-arginine in patients with essential hypertension
77. Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels
78. Angiotensin-converting enzyme inhibition alters nitric oxide and superoxide release in normotensive and hypertensive rats
79. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone
80. Hypertension in renal parenchymal disease
81. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
82. Impaired endothelium-dependent relaxation in mesenteric arteries of reduced renal mass hypertensive rats
83. Physiology and biochemistry of endothelial function in children with chronic renal failure
84. Impaired endothelium-dependent vasodilatation in renal failure in humans
85. Oxidative stress in chronic renal failure
86. Alteration in plasma antioxidant capacity in various degrees of chronic renal failure
87. Oxidative stress in chronic renal failure
88. Magnesium lithospermate B suppresses the increase of active oxygen in rats after subtotal nephrectomy
89. Antioxidant enzyme gene expression in rats with remnant kidney induced chronic renal failure
90. Glomerulosclerosis in the remnant kidney rat is modulated by dietary alpha-tocopherol
91. Role of increased oxygen free radical activity in the pathogenesis of uremic hypertension
92. Hypertension after 5/6 nephrectomy in rats is caused by increased vascular superoxide production