Vascular endothelial growth factor-165 overexpression stimulates angiogenesis and induces cyst formation and macrophage infiltration in human ovarian cancer xenografts

American Journal of Pathology

Volumn 160, Issue 2, 2002, Pages 537-548

  Duyndam, Monique C A ^a   Hilhorst, Marion C G W ^a   Schlüper, Hennie M M ^a   Verheul, Henk M W ^a   Van Diest, Paul J ^a   Kraal, Georg ^a   Pinedo, Herbert M ^a   Boven, Epie ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 165;

ALTERNATIVE RNA SPLICING; ANGIOGENESIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER SURVIVAL; CELL PROLIFERATION; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MOLECULAR CLONING; OVARY CANCER; OVARY CYST; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

EID: 0036174025     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64873-0     Document Type: Article

References (46)

1. Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine
2. The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
3. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
4. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix
5. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
6. The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
7. Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells
8. Neuropilin-1 is expressed by endothelial and tumor cells as an isoformspecific receptor for vascular endothelial growth factor
9. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor fit-1
10. Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation
11. Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma
12. Vascular permeability factor gene expression in normal and neoplastic human ovaries
13. Expression and localization of the vascular endothelial growth factor family in ovarian epithelial tumors
14. Expression of vascular endothelial growth factor and its receptors fit and KDR in ovarian carcinoma
15. Vascular endothelial growth factor expression in early stage ovarian carcinoma
16. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: Correlation with clinicopathology and patient survival, and analysis of serum VEGF levels
17. Tumor angiogenesis in advanced stage ovarian carcinoma
18. Pathogenesis of ascites tumor growth: Vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation
19. Role of vascular endothelial growth factor in ovarian cancer: Inhibition of ascites formation by immunoneutralization
20. Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with nodepositive breast cancer treated with either adjuvant chemotherapy or hormone therapy
21. High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer
22. Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors
23. Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations
24. A new technique for the assay of infectivity of human adenovirus 5 DNA
25. Activation of the human beta-interferon gene requires an interferon-inducible factor
26. Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung
27. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
28. Human ovarian cancer xenografts in nude mice: Characterization and analysis of antigen expression
29. Microvessel density and distribution in ductal carcinoma in situ of the breast
30. Molecular and biological properties of the vascular endothelial growth factor family of proteins
31. Vascular endothelial growth factor levels in ovarian cyst fluid correlate with malignancy
32. Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas
33. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
34. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer
35. Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells
36. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
37. Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells
38. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
39. Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts
40. The origin and function of tumor-associated macrophages
41. Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents
42. Cytokine regulation of angiogenesis in breast cancer: The role of tumor-associated macrophages
43. Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas
44. Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: Potential inhibition of angiogenesis
45. Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers