Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perijá leads to the loss of thrombin proteolytic activity

Thrombosis and Haemostasis

Volumn 87, Issue 2, 2002, Pages 282-287

  Sekine, Osamu ^a   Sugo, Teruko ^a   Ebisawa, Kazuyoshi ^a   Umeyama, Hideaki ^a   Iwahana, Hiroyuki ^a   Ruiz Sáez, Arlette ^a   De Bosch, Norma ^a   Matsuda, Michio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Dysprothrombin; Proteolytic activity; Prothrombin; Steric hindrance; Substrate binding pocket

Indexed keywords

ALANINE; ANTITHROMBIN III; ARGININE; BLOOD CLOTTING FACTOR 10A; DNA; DYFLOS; FIBRINOGEN; GLYCINE; GUANIDINE DERIVATIVE; HEPARIN; METHYL GROUP; NUCLEOTIDE; PROTEIN C; PROTHROMBIN; PROTHROMBIN PERIJA; SERINE; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DYSPROTHROMBINEMIA; EXON; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HOMOZYGOSITY; HUMAN; MALE; MOLECULAR DYNAMICS; MOLECULE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

EID: 0036173282     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1612986     Document Type: Article

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