Lecithin: Cholesterol acyltransferase is insufficient to prevent oxidative modification of low-density lipoprotein

Journal of Biochemistry

Volumn 131, Issue 1, 2002, Pages 17-19

  Murakami, Youhei ^a   Kamiyama, Shin ^a   Howlader, Zakir H ^a   Yamato, Tokuhisa ^a   Komai, Michio ^a   Furukawa, Yuji ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Antioxidation; High density lipoprotein; Lecithin:cholesterol acyltransferase; Low density lipoprotein; Oxidation

Indexed keywords

LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; OXIDATION;

EID: 0036172686     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003072     Document Type: Article

References (11)

1. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: Recognition by receptors for acetylated low density lipoproteins
2. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
3. A novel lecithin-cholesterol acyltransferase antioxidant activity prevents the formation of oxidized lipids during lipoprotein oxidation
4. The plasma lecithins:cholesterol acyltransferase reaction
5. Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles
6. Lecithin:cholesterol acyltransferase reduces the adverse effects of oxidized low-density lipoprorein while incurring damage itself
7. Inhibitory effects of oxidized low-density lipoprotein on the activity of plasma lecithin:cholesterol acyltransferase
8. Inhibitory effects of lipid oxidation on the activity of plasma lecithin:cholesterol acyltransferase
9. Reaction of phosphatidylcholine hydroperoxide in human plasma: The role of peroxidase and lecithin:cholesterol acyltransferase
10. Novel function of lecithin-cholesterol acyltransferase. Hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation
11. Metabolism of oxidized phosphatidylcholines formed in oxidized low density lipoprotein by lecithin-cholesterol acyltransferase